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Prognostic significance of TMEM16A, PPFIA1, and FADD expression in invasive ductal carcinoma of the breast
BACKGROUND: 11q13 region is a frequently amplified locus in human malignancies. Among the genes located in this region, FADD is one of the alleged driving genes. Because amplification is not generally confined to a single gene and amplified genes may not show increased expression, we need to evaluat...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4028009/ https://www.ncbi.nlm.nih.gov/pubmed/24886289 http://dx.doi.org/10.1186/1477-7819-12-137 |
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author | Choi, Eun Ji Yun, Jeong A Jabeen, Sahrish Jeon, Eun Kyoung Won, Hye Sung Ko, Yoon Ho Kim, Su Young |
author_facet | Choi, Eun Ji Yun, Jeong A Jabeen, Sahrish Jeon, Eun Kyoung Won, Hye Sung Ko, Yoon Ho Kim, Su Young |
author_sort | Choi, Eun Ji |
collection | PubMed |
description | BACKGROUND: 11q13 region is a frequently amplified locus in human malignancies. Among the genes located in this region, FADD is one of the alleged driving genes. Because amplification is not generally confined to a single gene and amplified genes may not show increased expression, we need to evaluate clinical significance of changes occurring in 11q13 region to understand their roles in carcinogenesis. Therefore, we screened expressions of FADD and closely located genes (PPFIA1 and TMEM16A) and evaluated the expressions to find clinical significance in invasive ductal carcinoma of the breast. METHODS: Ninety-eight cases of invasive ductal carcinoma of the breast were collected. Using archival tissues resected from the cases, we built a tissue microarray and used it in immunohistochemistry. We evaluated the association of FADD, PPFIA1, and TMEM16A expression scores with clinicopathological parameters, including disease-free survival. RESULTS: FADD expression was associated with T stage (P = 0.046). The combined score of FADD, PPFIA1, and TMEM16A gene expressions was associated with perineural invasion (P = 0.022). Although individual gene expressions of TMEM16A, FADD, and PPFIA1 failed to show significant association with disease-free survival, combined gene expression scores did show association with disease-free survival (P = 0.034). CONCLUSIONS: FADD, TMEM16A, and PPFIA1 gene expressions as a whole were associated with disease-free survival in breast cancer. |
format | Online Article Text |
id | pubmed-4028009 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-40280092014-05-30 Prognostic significance of TMEM16A, PPFIA1, and FADD expression in invasive ductal carcinoma of the breast Choi, Eun Ji Yun, Jeong A Jabeen, Sahrish Jeon, Eun Kyoung Won, Hye Sung Ko, Yoon Ho Kim, Su Young World J Surg Oncol Research BACKGROUND: 11q13 region is a frequently amplified locus in human malignancies. Among the genes located in this region, FADD is one of the alleged driving genes. Because amplification is not generally confined to a single gene and amplified genes may not show increased expression, we need to evaluate clinical significance of changes occurring in 11q13 region to understand their roles in carcinogenesis. Therefore, we screened expressions of FADD and closely located genes (PPFIA1 and TMEM16A) and evaluated the expressions to find clinical significance in invasive ductal carcinoma of the breast. METHODS: Ninety-eight cases of invasive ductal carcinoma of the breast were collected. Using archival tissues resected from the cases, we built a tissue microarray and used it in immunohistochemistry. We evaluated the association of FADD, PPFIA1, and TMEM16A expression scores with clinicopathological parameters, including disease-free survival. RESULTS: FADD expression was associated with T stage (P = 0.046). The combined score of FADD, PPFIA1, and TMEM16A gene expressions was associated with perineural invasion (P = 0.022). Although individual gene expressions of TMEM16A, FADD, and PPFIA1 failed to show significant association with disease-free survival, combined gene expression scores did show association with disease-free survival (P = 0.034). CONCLUSIONS: FADD, TMEM16A, and PPFIA1 gene expressions as a whole were associated with disease-free survival in breast cancer. BioMed Central 2014-05-01 /pmc/articles/PMC4028009/ /pubmed/24886289 http://dx.doi.org/10.1186/1477-7819-12-137 Text en Copyright © 2014 Choi et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Choi, Eun Ji Yun, Jeong A Jabeen, Sahrish Jeon, Eun Kyoung Won, Hye Sung Ko, Yoon Ho Kim, Su Young Prognostic significance of TMEM16A, PPFIA1, and FADD expression in invasive ductal carcinoma of the breast |
title | Prognostic significance of TMEM16A, PPFIA1, and FADD expression in invasive ductal carcinoma of the breast |
title_full | Prognostic significance of TMEM16A, PPFIA1, and FADD expression in invasive ductal carcinoma of the breast |
title_fullStr | Prognostic significance of TMEM16A, PPFIA1, and FADD expression in invasive ductal carcinoma of the breast |
title_full_unstemmed | Prognostic significance of TMEM16A, PPFIA1, and FADD expression in invasive ductal carcinoma of the breast |
title_short | Prognostic significance of TMEM16A, PPFIA1, and FADD expression in invasive ductal carcinoma of the breast |
title_sort | prognostic significance of tmem16a, ppfia1, and fadd expression in invasive ductal carcinoma of the breast |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4028009/ https://www.ncbi.nlm.nih.gov/pubmed/24886289 http://dx.doi.org/10.1186/1477-7819-12-137 |
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