Flanking Sequence Specificity Determines Coding Microsatellite Heteroduplex and Mutation Rates with Defective DNA Mismatch Repair (MMR)

The activin type II receptor (ACVR2) contains 2 identical microsatellites in exon 3 and 10, but only the exon 10 microsatellite is frameshifted in MMR-defective colonic tumors. The reason for this selectivity is not known. We hypothesized that ACVR2 frameshifts were influenced by DNA sequences surro...

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Detalles Bibliográficos
Autores principales: Chung, Heekyung, Lopez, Claudia G., Young, Dennis J., Lai, Jenny F., Holmstrom, Joy, Ream-Robinson, Deena, Cabrera, Betty L., Carethers, John M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4028169/
https://www.ncbi.nlm.nih.gov/pubmed/20140012
http://dx.doi.org/10.1038/onc.2009.508

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4028169/
https://www.ncbi.nlm.nih.gov/pubmed/20140012
http://dx.doi.org/10.1038/onc.2009.508

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