Cargando…
Distinguishing between Exploratory and Confirmatory Preclinical Research Will Improve Translation
Preclinical researchers confront two overarching agendas related to drug development: selecting interventions amid a vast field of candidates, and producing rigorous evidence of clinical promise for a small number of interventions. We suggest that each challenge is best met by two different, complem...
Autores principales: | Kimmelman, Jonathan, Mogil, Jeffrey S., Dirnagl, Ulrich |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4028181/ https://www.ncbi.nlm.nih.gov/pubmed/24844265 http://dx.doi.org/10.1371/journal.pbio.1001863 |
Ejemplares similares
-
The bench is closer to the bedside than we think: Uncovering the ethical ties between preclinical researchers in translational neuroscience and patients in clinical trials
por: Yarborough, Mark, et al.
Publicado: (2018) -
Increasing efficiency of preclinical research by group sequential designs
por: Neumann, Konrad, et al.
Publicado: (2017) -
Preregistration of exploratory research: Learning from the golden age of discovery
por: Dirnagl, Ulrich
Publicado: (2020) -
Improving Translational Relevance in Preclinical Psychopharmacology (iTRIPP)
por: Bailey, Sarah J, et al.
Publicado: (2023) -
True Negatives: Disseminating Research on Null, Inconclusive, and Confirmatory Findings in Cardiovascular Science
por: Nallamothu, Brahmajee K., et al.
Publicado: (2020)