Cargando…

Structural and Functional Insights into the Mode of Action of a Universally Conserved Obg GTPase

Obg proteins are a family of P-loop GTPases, conserved from bacteria to human. The Obg protein in Escherichia coli (ObgE) has been implicated in many diverse cellular functions, with proposed molecular roles in two global processes, ribosome assembly and stringent response. Here, using pre-steady st...

Descripción completa

Detalles Bibliográficos
Autores principales:	Feng, Boya, Mandava, Chandra Sekhar, Guo, Qiang, Wang, Jie, Cao, Wei, Li, Ningning, Zhang, Yixiao, Zhang, Yanqing, Wang, Zhixin, Wu, Jiawei, Sanyal, Suparna, Lei, Jianlin, Gao, Ning
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4028186/ https://www.ncbi.nlm.nih.gov/pubmed/24844575 http://dx.doi.org/10.1371/journal.pbio.1001866

Ejemplares similares

Targeting an Essential GTPase Obg for the Development of Broad-Spectrum Antibiotics
por: Bonventre, Josephine A., et al.
Publicado: (2016)

YbiB: a novel interactor of the GTPase ObgE
por: Deckers, Babette, et al.
Publicado: (2023)

Cryo-EM shows stages of initial codon selection on the ribosome by aa-tRNA in ternary complex with GTP and the GTPase-deficient EF-Tu(H84A)
por: Fislage, Marcus, et al.
Publicado: (2018)

A conserved histidine in switch-II of EF-G moderates release of inorganic phosphate
por: Kiran Koripella, Ravi, et al.
Publicado: (2015)

A single-step method for purification of active His-tagged ribosomes from a genetically engineered Escherichia coli
por: Ederth, Josefine, et al.
Publicado: (2009)

The mechanism of error induction by the antibiotic viomycin provides insight into the fidelity mechanism of translation
por: Holm, Mikael, et al.
Publicado: (2019)

Optimization of a fluorescent-mRNA based real-time assay for precise kinetic measurements of ribosomal translocation
por: Kim, Changil, et al.
Publicado: (2021)

Structural insights into the function of a unique tandem GTPase EngA in bacterial ribosome assembly
por: Zhang, Xiaoxiao, et al.
Publicado: (2014)

The Neisseria gonorrhoeae Obg protein is an essential ribosome-associated GTPase and a potential drug target
por: Zielke, Ryszard A., et al.
Publicado: (2015)

GTP Binding Is Necessary for the Activation of a Toxic Mutant Isoform of the Essential GTPase ObgE
por: Dewachter, Liselot, et al.
Publicado: (2019)

The structure–function analysis of Obg‐like GTPase proteins along the evolutionary tree from bacteria to humans
por: Chakraborty, Asmita, et al.
Publicado: (2022)

Mechanistic insights into translation inhibition by aminoglycoside antibiotic arbekacin
por: Parajuli, Narayan Prasad, et al.
Publicado: (2021)

Antibiotic thermorubin tethers ribosomal subunits and impedes A-site interactions to perturb protein synthesis in bacteria
por: Parajuli, Narayan Prasad, et al.
Publicado: (2023)

Insights into translocation mechanism and ribosome evolution from cryo-EM structures of translocation intermediates of Giardia intestinalis
por: Majumdar, Soneya, et al.
Publicado: (2023)

Bacterial ribosome requires multiple L12 dimers for efficient initiation and elongation of protein synthesis involving IF2 and EF-G
por: Mandava, Chandra Sekhar, et al.
Publicado: (2012)

Lamotrigine compromises the fidelity of initiator tRNA recruitment to the ribosomal P-site by IF2 and the RbfA release from 30S ribosomes in Escherichia coli
por: Singh, Sudhir, et al.
Publicado: (2023)

Rice TSV3 Encoding Obg-Like GTPase Protein Is Essential for Chloroplast Development During the Early Leaf Stage Under Cold Stress
por: Lin, Dongzhi, et al.
Publicado: (2017)

The human Obg protein GTPBP10 is involved in mitoribosomal biogenesis
por: Lavdovskaia, Elena, et al.
Publicado: (2018)

Structure and function of FusB: an elongation factor G-binding fusidic acid resistance protein active in ribosomal translocation and recycling
por: Guo, Xiaohu, et al.
Publicado: (2012)

Biochemical and physiological characterization of the GTP-binding protein Obg of Mycobacterium tuberculosis
por: Sasindran, Smitha J, et al.
Publicado: (2011)

Molecular Modeling Study for Interaction between Bacillus subtilis Obg and Nucleotides
por: Lee, Yuno, et al.
Publicado: (2010)

GTPase modes modeled
por: LeBrasseur, Nicole
Publicado: (2004)

Reactive oxygen species do not contribute to ObgE*-mediated programmed cell death
por: Dewachter, Liselot, et al.
Publicado: (2016)

The bacterial cell cycle checkpoint protein Obg and its role in programmed cell death
por: Dewachter, Liselot, et al.
Publicado: (2016)

A Mutant Isoform of ObgE Causes Cell Death by Interfering with Cell Division
por: Dewachter, Liselot, et al.
Publicado: (2017)

Attenuation of a Pathogenic Mycoplasma Strain by Modification of the obg Gene by Using Synthetic Biology Approaches
por: Lartigue, Carole, et al.
Publicado: (2019)

Oryza sativa ObgC1 Acts as a Key Regulator of DNA Replication and Ribosome Biogenesis in Chloroplast Nucleoids
por: Chen, Ji, et al.
Publicado: (2021)

Obg-Like ATPase 1 Enhances Chemoresistance of Breast Cancer via Activation of TGF-β/Smad Axis Cascades
por: Liu, Jianzhou, et al.
Publicado: (2020)

Repurposing tRNAs for nonsense suppression
por: Albers, Suki, et al.
Publicado: (2021)

OLA-1, an Obg-like ATPase, integrates hunger with temperature information in sensory neurons in C. elegans
por: Aoki, Ichiro, et al.
Publicado: (2022)

Cryo-EM structure of Mycobacterium smegmatis ribosome reveals two unidentified ribosomal proteins close to the functional centers
por: Li, Zhifei, et al.
Publicado: (2017)

Complementation of the Mycoplasma synoviae MS-H vaccine strain with wild-type obg influencing its growth characteristics
por: Shahid, Muhammad A., et al.
Publicado: (2018)

A Single-Amino-Acid Substitution in Obg Activates a New Programmed Cell Death Pathway in Escherichia coli
por: Dewachter, Liselot, et al.
Publicado: (2015)

Mutations in GTP Binding Protein Obg of Mycoplasma synoviae Vaccine Strain MS-H: Implications in Temperature-Sensitivity Phenotype
por: Shahid, Muhammad A., et al.
Publicado: (2013)

The Small GTPases in Fungal Signaling Conservation and Function
por: Dautt-Castro, Mitzuko, et al.
Publicado: (2021)

Obg-like ATPase 1 inhibited oral carcinoma cell metastasis through TGFβ/SMAD2 axis in vitro
por: Liu, Jianzhou, et al.
Publicado: (2020)

Obg-like ATPase 1 (OLA1) overexpression predicts poor prognosis and promotes tumor progression by regulating P21/CDK2 in hepatocellular carcinoma
por: Huang, Shanzhou, et al.
Publicado: (2020)

A Dual Binding Mode for RhoGTPases in Plexin Signalling
por: Bell, Christian H., et al.
Publicado: (2011)

Interactome and evolutionary conservation of Dictyostelid small GTPases and their direct regulators
por: Forbes, Gillian, et al.
Publicado: (2021)

Human G-proteins, ObgH1 and Mtg1, associate with the large mitochondrial ribosome subunit and are involved in translation and assembly of respiratory complexes
por: Kotani, Tetsuya, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_tgccu7dto2easmm2eaa3kdaajv