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Provocation of Symmetry/Ordering Symptoms in Anorexia nervosa: A Functional Neuroimaging Study
Anorexia nervosa (AN), obsessive–compulsive disorder (OCD), and obsessive–compulsive personality disorder (OCPD) are often co-morbid; however, the aetiology of such co-morbidity has not been well investigated. This study examined brain activation in women with AN and in healthy control (HC) women du...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4028263/ https://www.ncbi.nlm.nih.gov/pubmed/24844926 http://dx.doi.org/10.1371/journal.pone.0097998 |
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author | Suda, Masashi Brooks, Samantha J. Giampietro, Vincent Uher, Rudolf Mataix-Cols, David Brammer, Michael J. Williams, Steven C. R. Treasure, Janet Campbell, Iain C. |
author_facet | Suda, Masashi Brooks, Samantha J. Giampietro, Vincent Uher, Rudolf Mataix-Cols, David Brammer, Michael J. Williams, Steven C. R. Treasure, Janet Campbell, Iain C. |
author_sort | Suda, Masashi |
collection | PubMed |
description | Anorexia nervosa (AN), obsessive–compulsive disorder (OCD), and obsessive–compulsive personality disorder (OCPD) are often co-morbid; however, the aetiology of such co-morbidity has not been well investigated. This study examined brain activation in women with AN and in healthy control (HC) women during the provocation of symmetry/ordering-related anxiety. During provocation, patients with AN showed more anxiety compared to HCs, which was correlated with the severity of symmetry/ordering symptoms. Activation in the right parietal lobe and right prefrontal cortex (rPFC) in response to provocation was reduced in the AN group compared with the HC group. The reduced right parietal activation observed in the AN group is consistent with parietal lobe involvement in visuospatial cognition and with studies of OCD reporting an association between structural abnormalities in this region and the severity of ‘ordering’ symptoms. Reduced rPFC activation in response to symmetry/ordering provocation has similarities with some, but not all, data collected from patients with AN who were exposed to images of food and bodies. Furthermore, the combination of data from the AN and HC groups showed that rPFC activation during symptom provocation was inversely correlated with the severity of symmetry/ordering symptoms. These data suggest that individuals with AN have a diminished ability to cognitively deal with illness-associated symptoms of provocation. Furthermore, our data also suggest that symptom provocation can progressively overload attempts by the rPFC to exert cognitive control. These findings are discussed in the context of the current neurobiological models of AN. |
format | Online Article Text |
id | pubmed-4028263 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-40282632014-05-21 Provocation of Symmetry/Ordering Symptoms in Anorexia nervosa: A Functional Neuroimaging Study Suda, Masashi Brooks, Samantha J. Giampietro, Vincent Uher, Rudolf Mataix-Cols, David Brammer, Michael J. Williams, Steven C. R. Treasure, Janet Campbell, Iain C. PLoS One Research Article Anorexia nervosa (AN), obsessive–compulsive disorder (OCD), and obsessive–compulsive personality disorder (OCPD) are often co-morbid; however, the aetiology of such co-morbidity has not been well investigated. This study examined brain activation in women with AN and in healthy control (HC) women during the provocation of symmetry/ordering-related anxiety. During provocation, patients with AN showed more anxiety compared to HCs, which was correlated with the severity of symmetry/ordering symptoms. Activation in the right parietal lobe and right prefrontal cortex (rPFC) in response to provocation was reduced in the AN group compared with the HC group. The reduced right parietal activation observed in the AN group is consistent with parietal lobe involvement in visuospatial cognition and with studies of OCD reporting an association between structural abnormalities in this region and the severity of ‘ordering’ symptoms. Reduced rPFC activation in response to symmetry/ordering provocation has similarities with some, but not all, data collected from patients with AN who were exposed to images of food and bodies. Furthermore, the combination of data from the AN and HC groups showed that rPFC activation during symptom provocation was inversely correlated with the severity of symmetry/ordering symptoms. These data suggest that individuals with AN have a diminished ability to cognitively deal with illness-associated symptoms of provocation. Furthermore, our data also suggest that symptom provocation can progressively overload attempts by the rPFC to exert cognitive control. These findings are discussed in the context of the current neurobiological models of AN. Public Library of Science 2014-05-20 /pmc/articles/PMC4028263/ /pubmed/24844926 http://dx.doi.org/10.1371/journal.pone.0097998 Text en © 2014 Suda et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Suda, Masashi Brooks, Samantha J. Giampietro, Vincent Uher, Rudolf Mataix-Cols, David Brammer, Michael J. Williams, Steven C. R. Treasure, Janet Campbell, Iain C. Provocation of Symmetry/Ordering Symptoms in Anorexia nervosa: A Functional Neuroimaging Study |
title | Provocation of Symmetry/Ordering Symptoms in Anorexia nervosa: A Functional Neuroimaging Study |
title_full | Provocation of Symmetry/Ordering Symptoms in Anorexia nervosa: A Functional Neuroimaging Study |
title_fullStr | Provocation of Symmetry/Ordering Symptoms in Anorexia nervosa: A Functional Neuroimaging Study |
title_full_unstemmed | Provocation of Symmetry/Ordering Symptoms in Anorexia nervosa: A Functional Neuroimaging Study |
title_short | Provocation of Symmetry/Ordering Symptoms in Anorexia nervosa: A Functional Neuroimaging Study |
title_sort | provocation of symmetry/ordering symptoms in anorexia nervosa: a functional neuroimaging study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4028263/ https://www.ncbi.nlm.nih.gov/pubmed/24844926 http://dx.doi.org/10.1371/journal.pone.0097998 |
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