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GGPPS1 predicts the biological character of hepatocellular carcinoma in patients with cirrhosis

BACKGROUND: Hepatocellular carcinoma (HCC) has been associated with diabetes and obesity, but a possible connection with the metabolic syndrome (MetS) and its potential interaction with hepatitis and cirrhosis are open to discussion. Our previous investigations have shown that GGPPS1 plays a critica...

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Autores principales: Yu, De-cai, Liu, Jia, Chen, Jun, Shao, Jiao-jiao, Shen, Xiao, Xia, Hong-guang, Li, Chao-jun, Xue, Bin, Ding, Yi-tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4028285/
https://www.ncbi.nlm.nih.gov/pubmed/24716791
http://dx.doi.org/10.1186/1471-2407-14-248
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author Yu, De-cai
Liu, Jia
Chen, Jun
Shao, Jiao-jiao
Shen, Xiao
Xia, Hong-guang
Li, Chao-jun
Xue, Bin
Ding, Yi-tao
author_facet Yu, De-cai
Liu, Jia
Chen, Jun
Shao, Jiao-jiao
Shen, Xiao
Xia, Hong-guang
Li, Chao-jun
Xue, Bin
Ding, Yi-tao
author_sort Yu, De-cai
collection PubMed
description BACKGROUND: Hepatocellular carcinoma (HCC) has been associated with diabetes and obesity, but a possible connection with the metabolic syndrome (MetS) and its potential interaction with hepatitis and cirrhosis are open to discussion. Our previous investigations have shown that GGPPS1 plays a critical role during hyperinsulinism. In this report, the expression and distribution of GGPPS1 in liver cancer, and its clinical significance were investigated. METHODS: 70 patients with hepatocellular carcinoma (HCC) were included in this study. Three different types of tissues from each HCC patient were assembled immediately after surgical resection: tumor-free tissue >5 cm far from tumor edge (TF), adjacent nonmalignant tissue within 2 cm (AT), and tissue from the tumor (TT). Normal liver tissues from 10 liver transplant donors served as healthy control (HC) while 10 patients with liver cirrhosis as cirrhosis control (CC). The expression and distribution of GGPPS1 were detected by immunohistochemistry, western blots, or real-time PCR. The relationship between the expression of GGPPS1 and clinic pathologic index were analyzed. RESULTS: We found that GGPPS1 was intensified mainly in the cytoplasm of liver tumor cells. Both the expression of GGPPS1 mRNA and protein were upregulated in TT comparing to AT or TF. Meanwhile, HCC patients with cirrhosis had relative higher expression of GGPPS1. In addition, many pathologic characters show close correlation with GGPPS1, such as tumor stage, vessel invasion, and early recurrence. CONCLUSION: GGPPS1 may play a critical role during the development of HCC from cirrhosis and is of clinical significance for predicting biological character of HCC.
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spelling pubmed-40282852014-05-21 GGPPS1 predicts the biological character of hepatocellular carcinoma in patients with cirrhosis Yu, De-cai Liu, Jia Chen, Jun Shao, Jiao-jiao Shen, Xiao Xia, Hong-guang Li, Chao-jun Xue, Bin Ding, Yi-tao BMC Cancer Research Article BACKGROUND: Hepatocellular carcinoma (HCC) has been associated with diabetes and obesity, but a possible connection with the metabolic syndrome (MetS) and its potential interaction with hepatitis and cirrhosis are open to discussion. Our previous investigations have shown that GGPPS1 plays a critical role during hyperinsulinism. In this report, the expression and distribution of GGPPS1 in liver cancer, and its clinical significance were investigated. METHODS: 70 patients with hepatocellular carcinoma (HCC) were included in this study. Three different types of tissues from each HCC patient were assembled immediately after surgical resection: tumor-free tissue >5 cm far from tumor edge (TF), adjacent nonmalignant tissue within 2 cm (AT), and tissue from the tumor (TT). Normal liver tissues from 10 liver transplant donors served as healthy control (HC) while 10 patients with liver cirrhosis as cirrhosis control (CC). The expression and distribution of GGPPS1 were detected by immunohistochemistry, western blots, or real-time PCR. The relationship between the expression of GGPPS1 and clinic pathologic index were analyzed. RESULTS: We found that GGPPS1 was intensified mainly in the cytoplasm of liver tumor cells. Both the expression of GGPPS1 mRNA and protein were upregulated in TT comparing to AT or TF. Meanwhile, HCC patients with cirrhosis had relative higher expression of GGPPS1. In addition, many pathologic characters show close correlation with GGPPS1, such as tumor stage, vessel invasion, and early recurrence. CONCLUSION: GGPPS1 may play a critical role during the development of HCC from cirrhosis and is of clinical significance for predicting biological character of HCC. BioMed Central 2014-04-09 /pmc/articles/PMC4028285/ /pubmed/24716791 http://dx.doi.org/10.1186/1471-2407-14-248 Text en Copyright © 2014 Yu et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
spellingShingle Research Article
Yu, De-cai
Liu, Jia
Chen, Jun
Shao, Jiao-jiao
Shen, Xiao
Xia, Hong-guang
Li, Chao-jun
Xue, Bin
Ding, Yi-tao
GGPPS1 predicts the biological character of hepatocellular carcinoma in patients with cirrhosis
title GGPPS1 predicts the biological character of hepatocellular carcinoma in patients with cirrhosis
title_full GGPPS1 predicts the biological character of hepatocellular carcinoma in patients with cirrhosis
title_fullStr GGPPS1 predicts the biological character of hepatocellular carcinoma in patients with cirrhosis
title_full_unstemmed GGPPS1 predicts the biological character of hepatocellular carcinoma in patients with cirrhosis
title_short GGPPS1 predicts the biological character of hepatocellular carcinoma in patients with cirrhosis
title_sort ggpps1 predicts the biological character of hepatocellular carcinoma in patients with cirrhosis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4028285/
https://www.ncbi.nlm.nih.gov/pubmed/24716791
http://dx.doi.org/10.1186/1471-2407-14-248
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