An observational study on the expression levels of MDM2 and MDMX proteins, and associated effects on P53 in a series of human liposarcomas

BACKGROUND: Inactivation of wild type P53 by its main cellular inhibitors (MDM2 and MDMX) is a well recognised feature of tumour formation in liposarcomas. MDM2 over-expression has been detected in approximately 80% of liposarcomas but only limited information is available about MDMX over-expression...

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Detalles Bibliográficos
Autores principales: Touqan, Nader, Diggle, Christine P, Verghese, Edlo T, Perry, Sarah, Horgan, Kieran, Merchant, William, Anwar, Rashida, Markham, Alexander F, Carr, Ian M, Achuthan, Rajgopal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4028812/
https://www.ncbi.nlm.nih.gov/pubmed/24330579
http://dx.doi.org/10.1186/1472-6890-13-32

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