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The anti-tumor effect of shikonin on osteosarcoma by inducing RIP1 and RIP3 dependent necroptosis

BACKGROUND: Osteosarcoma is the most frequent primary malignant bone tumor, notorious for its lung metastasis. Shikonin, an effective constituent extracted from Chinese medicinal herb, was demonstrated to induce necroptosis in some cancers. METHODS: MTT assay was performed to detect cell survival ra...

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Detalles Bibliográficos
Autores principales:	Fu, Zeze, Deng, Biyong, Liao, Yuxin, Shan, Liancheng, Yin, Fei, Wang, Zhuoying, Zeng, Hui, Zuo, Dongqing, Hua, Yingqi, Cai, Zhengdong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4028842/ https://www.ncbi.nlm.nih.gov/pubmed/24314238 http://dx.doi.org/10.1186/1471-2407-13-580

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