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Analysis of equivalent uniform dose (EUD) and conventional radiation treatment parameters after primary and re-irradiation of malignant glioma
BACKGROUND: Re-irradiation is a reasonable second treatment option for patients with recurrent malignant glioma (MG) after previous radio(chemo)therapy. However, only limited data is available allowing for a precise selection of patients suitable for re-treatment in regard to safety and efficacy. ME...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4029146/ https://www.ncbi.nlm.nih.gov/pubmed/24330746 http://dx.doi.org/10.1186/1748-717X-8-287 |
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author | Niyazi, Maximilian Karin, Ivan Söhn, Matthias Nachbichler, Silke B Lang, Peter Belka, Claus Ganswindt, Ute |
author_facet | Niyazi, Maximilian Karin, Ivan Söhn, Matthias Nachbichler, Silke B Lang, Peter Belka, Claus Ganswindt, Ute |
author_sort | Niyazi, Maximilian |
collection | PubMed |
description | BACKGROUND: Re-irradiation is a reasonable second treatment option for patients with recurrent malignant glioma (MG) after previous radio(chemo)therapy. However, only limited data is available allowing for a precise selection of patients suitable for re-treatment in regard to safety and efficacy. METHODS: Using the department database, 58 patients with two courses of percutaneous radiation were identified. Besides classical dose-volume histogram (DVH) parameters equivalent uniform dose (EUD) values were calculated for the tumor and organs at risk (OARs), retrospectively analyzed and correlated to survival outcome parameters. Cumulative EUD values were also calculated in all cases where previous OAR DVHs were available. RESULTS: Median follow-up was 265 days and no relevant toxicity was observed after re-irradiation in our patient cohort during follow-up. Time interval between first and second irradiation was regularly above 6 months. As a conservative estimation of the cumulative EUD to the OARs, the EUDs of first and second irradiation were added. Median cumulative EUD to the optic chiasm was 48.8 Gy (range, 2.5–76.5 Gy), 57.4 Gy (range, 2.7–75.3 Gy) to the brainstem, 20.9/22.1 Gy (range, 0.0–68.3 Gy) to the right/left optic nerve and 73.8 Gy (range, 64.9–77.3 Gy) to the brain. No correlation between treated volume and survival was seen. CONCLUSIONS: This study provides retrospective estimates on cumulative doses at the OARs. EUD values are derived and may serve as reference for further studies, including planning studies where specific constraints are needed. |
format | Online Article Text |
id | pubmed-4029146 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-40291462014-05-22 Analysis of equivalent uniform dose (EUD) and conventional radiation treatment parameters after primary and re-irradiation of malignant glioma Niyazi, Maximilian Karin, Ivan Söhn, Matthias Nachbichler, Silke B Lang, Peter Belka, Claus Ganswindt, Ute Radiat Oncol Research BACKGROUND: Re-irradiation is a reasonable second treatment option for patients with recurrent malignant glioma (MG) after previous radio(chemo)therapy. However, only limited data is available allowing for a precise selection of patients suitable for re-treatment in regard to safety and efficacy. METHODS: Using the department database, 58 patients with two courses of percutaneous radiation were identified. Besides classical dose-volume histogram (DVH) parameters equivalent uniform dose (EUD) values were calculated for the tumor and organs at risk (OARs), retrospectively analyzed and correlated to survival outcome parameters. Cumulative EUD values were also calculated in all cases where previous OAR DVHs were available. RESULTS: Median follow-up was 265 days and no relevant toxicity was observed after re-irradiation in our patient cohort during follow-up. Time interval between first and second irradiation was regularly above 6 months. As a conservative estimation of the cumulative EUD to the OARs, the EUDs of first and second irradiation were added. Median cumulative EUD to the optic chiasm was 48.8 Gy (range, 2.5–76.5 Gy), 57.4 Gy (range, 2.7–75.3 Gy) to the brainstem, 20.9/22.1 Gy (range, 0.0–68.3 Gy) to the right/left optic nerve and 73.8 Gy (range, 64.9–77.3 Gy) to the brain. No correlation between treated volume and survival was seen. CONCLUSIONS: This study provides retrospective estimates on cumulative doses at the OARs. EUD values are derived and may serve as reference for further studies, including planning studies where specific constraints are needed. BioMed Central 2013-12-13 /pmc/articles/PMC4029146/ /pubmed/24330746 http://dx.doi.org/10.1186/1748-717X-8-287 Text en Copyright © 2013 Niyazi et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Niyazi, Maximilian Karin, Ivan Söhn, Matthias Nachbichler, Silke B Lang, Peter Belka, Claus Ganswindt, Ute Analysis of equivalent uniform dose (EUD) and conventional radiation treatment parameters after primary and re-irradiation of malignant glioma |
title | Analysis of equivalent uniform dose (EUD) and conventional radiation treatment parameters after primary and re-irradiation of malignant glioma |
title_full | Analysis of equivalent uniform dose (EUD) and conventional radiation treatment parameters after primary and re-irradiation of malignant glioma |
title_fullStr | Analysis of equivalent uniform dose (EUD) and conventional radiation treatment parameters after primary and re-irradiation of malignant glioma |
title_full_unstemmed | Analysis of equivalent uniform dose (EUD) and conventional radiation treatment parameters after primary and re-irradiation of malignant glioma |
title_short | Analysis of equivalent uniform dose (EUD) and conventional radiation treatment parameters after primary and re-irradiation of malignant glioma |
title_sort | analysis of equivalent uniform dose (eud) and conventional radiation treatment parameters after primary and re-irradiation of malignant glioma |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4029146/ https://www.ncbi.nlm.nih.gov/pubmed/24330746 http://dx.doi.org/10.1186/1748-717X-8-287 |
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