The oncogenic properties of EWS/WT1 of desmoplastic small round cell tumors are unmasked by loss of p53 in murine embryonic fibroblasts

BACKGROUND: Desmoplastic small round cell tumor (DSRCT) is characterized by the presence of a fusion protein EWS/WT1, arising from the t (11;22) (p13;q12) translocation. Here we examine the oncogenic properties of two splice variants of EWS/WT1, EWS/WT1-KTS and EWS/WT1 + KTS. METHODS: We over-expres...

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Detalles Bibliográficos
Autores principales: Bandopadhayay, Pratiti, Jabbour, Anissa M, Riffkin, Christopher, Salmanidis, Marika, Gordon, Lavinia, Popovski, Dean, Rigby, Lin, Ashley, David M, Watkins, David N, Thomas, David M, Algar, Elizabeth, Ekert, Paul G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4029184/
https://www.ncbi.nlm.nih.gov/pubmed/24321497
http://dx.doi.org/10.1186/1471-2407-13-585

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