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BIM(EL) is a key effector molecule in oxidative stress-mediated apoptosis in acute myeloid leukemia cells when combined with arsenic trioxide and buthionine sulfoximine

ABSTRACTS: BACKGROUND: Arsenic trioxide (ATO) is reported to be an effective therapeutic agent in acute promyelocytic leukemia (APL) through inducing apoptotic cell death. Buthionine sulfoximine (BSO), an oxidative stress pathway modulator, is suggested as a potential combination therapy for ATO-ins...

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Detalles Bibliográficos
Autores principales:	Tanaka, Yukie, Komatsu, Takayuki, Shigemi, Hiroko, Yamauchi, Takahiro, Fujii, Yutaka
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4029189/ https://www.ncbi.nlm.nih.gov/pubmed/24428916 http://dx.doi.org/10.1186/1471-2407-14-27

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