Deregulation of subcellular biometal homeostasis through loss of the metal transporter, Zip7, in a childhood neurodegenerative disorder

BACKGROUND: Aberrant biometal metabolism is a key feature of neurodegenerative disorders including Alzheimer’s and Parkinson’s diseases. Metal modulating compounds are promising therapeutics for neurodegeneration, but their mechanism of action remains poorly understood. Neuronal ceroid lipofuscinose...

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Detalles Bibliográficos
Autores principales: Grubman, Alexandra, Lidgerwood, Grace E, Duncan, Clare, Bica, Laura, Tan, Jiang-Li, Parker, Sarah J, Caragounis, Aphrodite, Meyerowitz, Jodi, Volitakis, Irene, Moujalled, Diane, Liddell, Jeffrey R, Hickey, James L, Horne, Malcolm, Longmuir, Shoshanah, Koistinaho, Jari, Donnelly, Paul S, Crouch, Peter J, Tammen, Imke, White, Anthony R, Kanninen, Katja M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4029264/
https://www.ncbi.nlm.nih.gov/pubmed/24581221
http://dx.doi.org/10.1186/2051-5960-2-25

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