Deficient spontaneous in vitro apoptosis and increased tmTNF reverse signaling-induced apoptosis of monocytes predict suboptimal therapeutic response of rheumatoid arthritis to TNF inhibition

INTRODUCTION: In vitro apoptosis of peripheral monocytes in rheumatoid arthritis (RA) is disturbed and influenced by cytokine production and transmembrane TNF (tmTNF) reverse signaling. The goal of the study was the analysis of the predictive value of the rate of in vitro apoptosis for the therapeut...

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Detalles Bibliográficos
Autores principales: Meusch, Undine, Klingner, Maria, Baerwald, Christoph, Rossol, Manuela, Wagner, Ulf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4029313/
https://www.ncbi.nlm.nih.gov/pubmed/24354986
http://dx.doi.org/10.1186/ar4416

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