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Design considerations for an integrated microphysiological muscle tissue for drug and tissue toxicity testing
Microphysiological systems provide a tool to simulate normal and pathological function of organs for prolonged periods. These systems must incorporate the key functions of the individual organs and enable interactions among the corresponding microphysiological units. The relative size of different m...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4029361/ https://www.ncbi.nlm.nih.gov/pubmed/24565225 http://dx.doi.org/10.1186/scrt371 |
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author | Truskey, George A Achneck, Hardean E Bursac, Nenad Chan, Hon Fai Cheng, Cindy S Fernandez, Cristina Hong, Sungmin Jung, Youngmee Koves, Tim Kraus, William E Leong, Kam Madden, Lauran Reichert, William M Zhao, Xuanhe |
author_facet | Truskey, George A Achneck, Hardean E Bursac, Nenad Chan, Hon Fai Cheng, Cindy S Fernandez, Cristina Hong, Sungmin Jung, Youngmee Koves, Tim Kraus, William E Leong, Kam Madden, Lauran Reichert, William M Zhao, Xuanhe |
author_sort | Truskey, George A |
collection | PubMed |
description | Microphysiological systems provide a tool to simulate normal and pathological function of organs for prolonged periods. These systems must incorporate the key functions of the individual organs and enable interactions among the corresponding microphysiological units. The relative size of different microphysiological organs and their flow rates are scaled in proportion to in vivo values. We have developed a microphysiological three-dimensional engineered human skeletal muscle system connected to a circulatory system that consists of a tissue-engineered blood vessel as part of a high-pressure arterial system. The engineered human skeletal muscle tissue reproduces key mechanical behaviors of skeletal muscle in vivo. Pulsatile flow is produced using a novel computer-controlled magnetically activated ferrogel. The system is versatile and the muscle unit can be integrated with other organ systems. Periodic monitoring of biomechanical function provides a non-invasive assessment of the health of the tissue and a way to measure the response to drugs and toxins. |
format | Online Article Text |
id | pubmed-4029361 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-40293612014-12-20 Design considerations for an integrated microphysiological muscle tissue for drug and tissue toxicity testing Truskey, George A Achneck, Hardean E Bursac, Nenad Chan, Hon Fai Cheng, Cindy S Fernandez, Cristina Hong, Sungmin Jung, Youngmee Koves, Tim Kraus, William E Leong, Kam Madden, Lauran Reichert, William M Zhao, Xuanhe Stem Cell Res Ther Review Microphysiological systems provide a tool to simulate normal and pathological function of organs for prolonged periods. These systems must incorporate the key functions of the individual organs and enable interactions among the corresponding microphysiological units. The relative size of different microphysiological organs and their flow rates are scaled in proportion to in vivo values. We have developed a microphysiological three-dimensional engineered human skeletal muscle system connected to a circulatory system that consists of a tissue-engineered blood vessel as part of a high-pressure arterial system. The engineered human skeletal muscle tissue reproduces key mechanical behaviors of skeletal muscle in vivo. Pulsatile flow is produced using a novel computer-controlled magnetically activated ferrogel. The system is versatile and the muscle unit can be integrated with other organ systems. Periodic monitoring of biomechanical function provides a non-invasive assessment of the health of the tissue and a way to measure the response to drugs and toxins. BioMed Central 2013-12-20 /pmc/articles/PMC4029361/ /pubmed/24565225 http://dx.doi.org/10.1186/scrt371 Text en Copyright © 2013 BioMed Central Ltd |
spellingShingle | Review Truskey, George A Achneck, Hardean E Bursac, Nenad Chan, Hon Fai Cheng, Cindy S Fernandez, Cristina Hong, Sungmin Jung, Youngmee Koves, Tim Kraus, William E Leong, Kam Madden, Lauran Reichert, William M Zhao, Xuanhe Design considerations for an integrated microphysiological muscle tissue for drug and tissue toxicity testing |
title | Design considerations for an integrated microphysiological muscle tissue for drug and tissue toxicity testing |
title_full | Design considerations for an integrated microphysiological muscle tissue for drug and tissue toxicity testing |
title_fullStr | Design considerations for an integrated microphysiological muscle tissue for drug and tissue toxicity testing |
title_full_unstemmed | Design considerations for an integrated microphysiological muscle tissue for drug and tissue toxicity testing |
title_short | Design considerations for an integrated microphysiological muscle tissue for drug and tissue toxicity testing |
title_sort | design considerations for an integrated microphysiological muscle tissue for drug and tissue toxicity testing |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4029361/ https://www.ncbi.nlm.nih.gov/pubmed/24565225 http://dx.doi.org/10.1186/scrt371 |
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