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Expression of MACC1 and c-Met in human gastric cancer and its clinical significance

BACKGROUND: Recent studies have suggested that the metastasis-associated colon cancer1 (MACC1) gene can promote tumor proliferation, invasion and metastasis through an upregulation of c-Met expression. However, its role in gastric cancer is controversial. Our study investigated expression of MACC1 a...

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Autores principales: Guo, Tiankang, Yang, Jingyu, Yao, Jibin, Zhang, Yongbin, Da, Mingxu, Duan, Yaoxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4029370/
https://www.ncbi.nlm.nih.gov/pubmed/24325214
http://dx.doi.org/10.1186/1475-2867-13-121
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author Guo, Tiankang
Yang, Jingyu
Yao, Jibin
Zhang, Yongbin
Da, Mingxu
Duan, Yaoxing
author_facet Guo, Tiankang
Yang, Jingyu
Yao, Jibin
Zhang, Yongbin
Da, Mingxu
Duan, Yaoxing
author_sort Guo, Tiankang
collection PubMed
description BACKGROUND: Recent studies have suggested that the metastasis-associated colon cancer1 (MACC1) gene can promote tumor proliferation, invasion and metastasis through an upregulation of c-Met expression. However, its role in gastric cancer is controversial. Our study investigated expression of MACC1 and c-Met in gastric cancer, as well as correlated this with clinicopathological parameters. METHODS: Expressions of MACC1 and c-Met protein in a sample of 98 gastric carcinoma and adjacent nontumorous tissues were detected by immunohistochemistry. Their relationships and correlations with clinicopathological features were analyzed. RESULTS: The positive rates of MACC1 and c-Met protein in primary tumors were 61.22% and 59.18%, respectively. A significant correlation was found between expression of MACC1 and c-Met (P<0.05). Expression of the MACC1 protein in gastric cancer tissue was correlated with lymph node metastasis (χ(2) = 10.555,P = 0.001), peritoneal metastasis (χ(2) = 5.694, P = 0.017), and hepatic metastasis (χ(2) = 4.540,P = 0.033), but not with age, gender, tumor size, location, clinical stage or the distant metastases (P>0.05). CONCLUSION: The positive rate of MACC1 protein expression was related to the protein expression of c-Met. Both had a correlation with the presence of peritoneal metastasis, lymph node metastasis and hepatic metastasis, all of which contribute to a poor prognosis for gastric cancer patients.
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spelling pubmed-40293702014-05-22 Expression of MACC1 and c-Met in human gastric cancer and its clinical significance Guo, Tiankang Yang, Jingyu Yao, Jibin Zhang, Yongbin Da, Mingxu Duan, Yaoxing Cancer Cell Int Primary Research BACKGROUND: Recent studies have suggested that the metastasis-associated colon cancer1 (MACC1) gene can promote tumor proliferation, invasion and metastasis through an upregulation of c-Met expression. However, its role in gastric cancer is controversial. Our study investigated expression of MACC1 and c-Met in gastric cancer, as well as correlated this with clinicopathological parameters. METHODS: Expressions of MACC1 and c-Met protein in a sample of 98 gastric carcinoma and adjacent nontumorous tissues were detected by immunohistochemistry. Their relationships and correlations with clinicopathological features were analyzed. RESULTS: The positive rates of MACC1 and c-Met protein in primary tumors were 61.22% and 59.18%, respectively. A significant correlation was found between expression of MACC1 and c-Met (P<0.05). Expression of the MACC1 protein in gastric cancer tissue was correlated with lymph node metastasis (χ(2) = 10.555,P = 0.001), peritoneal metastasis (χ(2) = 5.694, P = 0.017), and hepatic metastasis (χ(2) = 4.540,P = 0.033), but not with age, gender, tumor size, location, clinical stage or the distant metastases (P>0.05). CONCLUSION: The positive rate of MACC1 protein expression was related to the protein expression of c-Met. Both had a correlation with the presence of peritoneal metastasis, lymph node metastasis and hepatic metastasis, all of which contribute to a poor prognosis for gastric cancer patients. BioMed Central 2013-12-10 /pmc/articles/PMC4029370/ /pubmed/24325214 http://dx.doi.org/10.1186/1475-2867-13-121 Text en Copyright © 2013 Guo et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Primary Research
Guo, Tiankang
Yang, Jingyu
Yao, Jibin
Zhang, Yongbin
Da, Mingxu
Duan, Yaoxing
Expression of MACC1 and c-Met in human gastric cancer and its clinical significance
title Expression of MACC1 and c-Met in human gastric cancer and its clinical significance
title_full Expression of MACC1 and c-Met in human gastric cancer and its clinical significance
title_fullStr Expression of MACC1 and c-Met in human gastric cancer and its clinical significance
title_full_unstemmed Expression of MACC1 and c-Met in human gastric cancer and its clinical significance
title_short Expression of MACC1 and c-Met in human gastric cancer and its clinical significance
title_sort expression of macc1 and c-met in human gastric cancer and its clinical significance
topic Primary Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4029370/
https://www.ncbi.nlm.nih.gov/pubmed/24325214
http://dx.doi.org/10.1186/1475-2867-13-121
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