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There are not enough data to conclude that Monomethylsilanetriol is safe

This article is in response to Jugdaohsingh et al.: The silicon supplement ‘Monomethylsilanetriol’ is safe and increases the body pool of silicon in healthy Pre-menopausal women. Nutrition & Metabolism 2013 10:37: http://www.nutritionandmetabolism.com/content/10/1/37 The response from the author...

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Autor principal: Vanden Berghe, Dirk A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4029377/
https://www.ncbi.nlm.nih.gov/pubmed/24499245
http://dx.doi.org/10.1186/1743-7075-10-66
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author Vanden Berghe, Dirk A
author_facet Vanden Berghe, Dirk A
author_sort Vanden Berghe, Dirk A
collection PubMed
description This article is in response to Jugdaohsingh et al.: The silicon supplement ‘Monomethylsilanetriol’ is safe and increases the body pool of silicon in healthy Pre-menopausal women. Nutrition & Metabolism 2013 10:37: http://www.nutritionandmetabolism.com/content/10/1/37 The response from the authors is published as Jugdaohsingh et al.: Response to Prof D. Vanden Berghe letter: ‘There are not enough data to conclude that Monomethylsilanetriol is safe’. Nutrition & Metabolism 2013 10:65: http://www.nutritionandmetabolism.com/content/10/1/65 ABSTRACT: The authors claim that the silicon supplement 'Monomethylsilanetriol’ (MMST) is safe and is converted to orthosilicic acid (OSA) after ingestion. Critical analysis of the study results indicates that the presented data are insufficient to conclude that the use of MMST in food or food supplements is safe. Long term safety studies in humans and toxicological testing in vitro and in animals are an absolute requisite for such a conclusion but these are lacking in the present study and in the literature. Furthermore, none of the presented data show that MMST is actually converted to OSA, as OSA was not analyzed in neither serum or urine of supplemented subjects.
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spelling pubmed-40293772014-05-22 There are not enough data to conclude that Monomethylsilanetriol is safe Vanden Berghe, Dirk A Nutr Metab (Lond) Letter to the Editor This article is in response to Jugdaohsingh et al.: The silicon supplement ‘Monomethylsilanetriol’ is safe and increases the body pool of silicon in healthy Pre-menopausal women. Nutrition & Metabolism 2013 10:37: http://www.nutritionandmetabolism.com/content/10/1/37 The response from the authors is published as Jugdaohsingh et al.: Response to Prof D. Vanden Berghe letter: ‘There are not enough data to conclude that Monomethylsilanetriol is safe’. Nutrition & Metabolism 2013 10:65: http://www.nutritionandmetabolism.com/content/10/1/65 ABSTRACT: The authors claim that the silicon supplement 'Monomethylsilanetriol’ (MMST) is safe and is converted to orthosilicic acid (OSA) after ingestion. Critical analysis of the study results indicates that the presented data are insufficient to conclude that the use of MMST in food or food supplements is safe. Long term safety studies in humans and toxicological testing in vitro and in animals are an absolute requisite for such a conclusion but these are lacking in the present study and in the literature. Furthermore, none of the presented data show that MMST is actually converted to OSA, as OSA was not analyzed in neither serum or urine of supplemented subjects. BioMed Central 2013-10-25 /pmc/articles/PMC4029377/ /pubmed/24499245 http://dx.doi.org/10.1186/1743-7075-10-66 Text en Copyright © 2013 Vanden Berghe; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Letter to the Editor
Vanden Berghe, Dirk A
There are not enough data to conclude that Monomethylsilanetriol is safe
title There are not enough data to conclude that Monomethylsilanetriol is safe
title_full There are not enough data to conclude that Monomethylsilanetriol is safe
title_fullStr There are not enough data to conclude that Monomethylsilanetriol is safe
title_full_unstemmed There are not enough data to conclude that Monomethylsilanetriol is safe
title_short There are not enough data to conclude that Monomethylsilanetriol is safe
title_sort there are not enough data to conclude that monomethylsilanetriol is safe
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4029377/
https://www.ncbi.nlm.nih.gov/pubmed/24499245
http://dx.doi.org/10.1186/1743-7075-10-66
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