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Retrospective study and immunohistochemical analysis of canine mammary sarcomas
BACKGROUND: Canine mammary sarcomas (CMSs) are rarely diagnosed in female dogs, which explains the scarcity of immunohistochemical findings concerning those tumors. This paper presents the results of a retrospective study into CMSs and discusses the clinical features of the analyzed tumors, the expr...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4029385/ https://www.ncbi.nlm.nih.gov/pubmed/24321325 http://dx.doi.org/10.1186/1746-6148-9-248 |
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author | Dolka, Izabella Sapierzyński, Rafał Król, Magdalena |
author_facet | Dolka, Izabella Sapierzyński, Rafał Król, Magdalena |
author_sort | Dolka, Izabella |
collection | PubMed |
description | BACKGROUND: Canine mammary sarcomas (CMSs) are rarely diagnosed in female dogs, which explains the scarcity of immunohistochemical findings concerning those tumors. This paper presents the results of a retrospective study into CMSs and discusses the clinical features of the analyzed tumors, the expression of intermediate filaments CK, Vim, Des and α-SMA, and the expression of p63, Ki67, ERα, PR and p53 protein. RESULTS: Four percent of all canine mammary tumors (CMTs) were classified as CMSs, and they represented 5.1% of malignant CMTs. The mean age at diagnosis was 11.1 ± 2.8 years. Large breed dogs were more frequently affected (38.7%). The majority of observed CMSs were fibrosarcomas (2.1%). All CMSs expressed vimentin, and higher levels of vimentin expression were noted in fibrosarcomas and osteosarcomas. Ki67 expression was significantly correlated with the grade of CMS. CONCLUSIONS: Our results revealed that CMSs form a heterogeneous group, therefore, immunohistochemical examinations could support differential and final diagnosis. Although this study analyzed a limited number of samples, the reported results can expand our knowledge about CMSs. Further work is required in this field. |
format | Online Article Text |
id | pubmed-4029385 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-40293852014-05-22 Retrospective study and immunohistochemical analysis of canine mammary sarcomas Dolka, Izabella Sapierzyński, Rafał Król, Magdalena BMC Vet Res Research Article BACKGROUND: Canine mammary sarcomas (CMSs) are rarely diagnosed in female dogs, which explains the scarcity of immunohistochemical findings concerning those tumors. This paper presents the results of a retrospective study into CMSs and discusses the clinical features of the analyzed tumors, the expression of intermediate filaments CK, Vim, Des and α-SMA, and the expression of p63, Ki67, ERα, PR and p53 protein. RESULTS: Four percent of all canine mammary tumors (CMTs) were classified as CMSs, and they represented 5.1% of malignant CMTs. The mean age at diagnosis was 11.1 ± 2.8 years. Large breed dogs were more frequently affected (38.7%). The majority of observed CMSs were fibrosarcomas (2.1%). All CMSs expressed vimentin, and higher levels of vimentin expression were noted in fibrosarcomas and osteosarcomas. Ki67 expression was significantly correlated with the grade of CMS. CONCLUSIONS: Our results revealed that CMSs form a heterogeneous group, therefore, immunohistochemical examinations could support differential and final diagnosis. Although this study analyzed a limited number of samples, the reported results can expand our knowledge about CMSs. Further work is required in this field. BioMed Central 2013-12-09 /pmc/articles/PMC4029385/ /pubmed/24321325 http://dx.doi.org/10.1186/1746-6148-9-248 Text en Copyright © 2013 Dolka et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Dolka, Izabella Sapierzyński, Rafał Król, Magdalena Retrospective study and immunohistochemical analysis of canine mammary sarcomas |
title | Retrospective study and immunohistochemical analysis of canine mammary sarcomas |
title_full | Retrospective study and immunohistochemical analysis of canine mammary sarcomas |
title_fullStr | Retrospective study and immunohistochemical analysis of canine mammary sarcomas |
title_full_unstemmed | Retrospective study and immunohistochemical analysis of canine mammary sarcomas |
title_short | Retrospective study and immunohistochemical analysis of canine mammary sarcomas |
title_sort | retrospective study and immunohistochemical analysis of canine mammary sarcomas |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4029385/ https://www.ncbi.nlm.nih.gov/pubmed/24321325 http://dx.doi.org/10.1186/1746-6148-9-248 |
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