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An epidemiological investigation into the association between biomarkers and growth performance in nursery pigs

BACKGROUND: Biomarkers are useful tools in research and clinical practice where they are often used to detect and monitor differences in the physiological state of an animal. The proteins IGF-1, IGFBP-3, GHR, CRP, SAA, Hp, IFN-α, IFN-γ, TNF-α, IL-1β, IL-6, IL-10, and IL-18 have been proposed as pote...

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Autores principales: Slifierz, Mackenzie J, Friendship, Robert, de Lange, Cornelius FM, Rudar, Marko, Farzan, Abdolvahab
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4029453/
https://www.ncbi.nlm.nih.gov/pubmed/24314007
http://dx.doi.org/10.1186/1746-6148-9-247
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author Slifierz, Mackenzie J
Friendship, Robert
de Lange, Cornelius FM
Rudar, Marko
Farzan, Abdolvahab
author_facet Slifierz, Mackenzie J
Friendship, Robert
de Lange, Cornelius FM
Rudar, Marko
Farzan, Abdolvahab
author_sort Slifierz, Mackenzie J
collection PubMed
description BACKGROUND: Biomarkers are useful tools in research and clinical practice where they are often used to detect and monitor differences in the physiological state of an animal. The proteins IGF-1, IGFBP-3, GHR, CRP, SAA, Hp, IFN-α, IFN-γ, TNF-α, IL-1β, IL-6, IL-10, and IL-18 have been proposed as potential biomarkers for monitoring growth in livestock. The objective of this study was to determine whether hepatic gene expression of these proposed biomarkers is associated with growth performance in nursery pigs. Herd information and growth parameters were collected for 168 piglets from 8 commercial farms in southern Ontario. From these pigs, a subset of liver tissue samples (n = 74) was used for gene expression analysis of the proposed biomarkers. Multivariable linear regression methods were used to determine whether genetic expression of the proposed biomarkers was associated with growth performance in the nursery. RESULTS: Modelling the herd information and individual piglet traits in relation to growth performance revealed that the weight at weaning and the age at weaning are significantly associated with nursery performance. Average daily gain (ADG) was significantly associated with hepatic IGFBP-3 and GHR expression in the liver (P < 0.05), and tended to be associated with hepatic IGF-1 expression (P = 0.071). Similarly, 9-week body weight was significantly associated with hepatic expression of IGFBP-3 and GHR expression (P < 0.05), and tended to be associated with hepatic expression of IGF-1 (P = 0.055). CONCLUSION: The age and weight at which pigs are weaned is an important determinant for nursery performance. Hepatic gene expression of IGF-1, IGFBP-3, and GHR can be useful biomarkers for monitoring growth performance in nursery pigs.
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spelling pubmed-40294532014-06-06 An epidemiological investigation into the association between biomarkers and growth performance in nursery pigs Slifierz, Mackenzie J Friendship, Robert de Lange, Cornelius FM Rudar, Marko Farzan, Abdolvahab BMC Vet Res Research Article BACKGROUND: Biomarkers are useful tools in research and clinical practice where they are often used to detect and monitor differences in the physiological state of an animal. The proteins IGF-1, IGFBP-3, GHR, CRP, SAA, Hp, IFN-α, IFN-γ, TNF-α, IL-1β, IL-6, IL-10, and IL-18 have been proposed as potential biomarkers for monitoring growth in livestock. The objective of this study was to determine whether hepatic gene expression of these proposed biomarkers is associated with growth performance in nursery pigs. Herd information and growth parameters were collected for 168 piglets from 8 commercial farms in southern Ontario. From these pigs, a subset of liver tissue samples (n = 74) was used for gene expression analysis of the proposed biomarkers. Multivariable linear regression methods were used to determine whether genetic expression of the proposed biomarkers was associated with growth performance in the nursery. RESULTS: Modelling the herd information and individual piglet traits in relation to growth performance revealed that the weight at weaning and the age at weaning are significantly associated with nursery performance. Average daily gain (ADG) was significantly associated with hepatic IGFBP-3 and GHR expression in the liver (P < 0.05), and tended to be associated with hepatic IGF-1 expression (P = 0.071). Similarly, 9-week body weight was significantly associated with hepatic expression of IGFBP-3 and GHR expression (P < 0.05), and tended to be associated with hepatic expression of IGF-1 (P = 0.055). CONCLUSION: The age and weight at which pigs are weaned is an important determinant for nursery performance. Hepatic gene expression of IGF-1, IGFBP-3, and GHR can be useful biomarkers for monitoring growth performance in nursery pigs. BioMed Central 2013-12-06 /pmc/articles/PMC4029453/ /pubmed/24314007 http://dx.doi.org/10.1186/1746-6148-9-247 Text en Copyright © 2013 Slifierz et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Slifierz, Mackenzie J
Friendship, Robert
de Lange, Cornelius FM
Rudar, Marko
Farzan, Abdolvahab
An epidemiological investigation into the association between biomarkers and growth performance in nursery pigs
title An epidemiological investigation into the association between biomarkers and growth performance in nursery pigs
title_full An epidemiological investigation into the association between biomarkers and growth performance in nursery pigs
title_fullStr An epidemiological investigation into the association between biomarkers and growth performance in nursery pigs
title_full_unstemmed An epidemiological investigation into the association between biomarkers and growth performance in nursery pigs
title_short An epidemiological investigation into the association between biomarkers and growth performance in nursery pigs
title_sort epidemiological investigation into the association between biomarkers and growth performance in nursery pigs
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4029453/
https://www.ncbi.nlm.nih.gov/pubmed/24314007
http://dx.doi.org/10.1186/1746-6148-9-247
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