Mechanical Stretch Suppresses microRNA-145 Expression by Activating Extracellular Signal-Regulated Kinase 1/2 and Upregulating Angiotensin-Converting Enzyme to Alter Vascular Smooth Muscle Cell Phenotype

Phenotype modulation of vascular smooth muscle cells (VSMCs) plays an important role in the pathogenesis of various vascular diseases, including hypertension and atherosclerosis. Several microRNAs (miRNAs) were found involved in regulating the VSMC phenotype with platelet-derived growth factor (PDGF...

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Detalles Bibliográficos
Autores principales: Hu, Bo, Song, Jian tao, Qu, Hai yan, Bi, Chen long, Huang, Xiao zhen, Liu, Xin xin, Zhang, Mei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4029552/
https://www.ncbi.nlm.nih.gov/pubmed/24848371
http://dx.doi.org/10.1371/journal.pone.0096338

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