Intranasal H5N1 Vaccines, Adjuvanted with Chitosan Derivatives, Protect Ferrets against Highly Pathogenic Influenza Intranasal and Intratracheal Challenge

We investigated the protective efficacy of two intranasal chitosan (CSN and TM-CSN) adjuvanted H5N1 Influenza vaccines against highly pathogenic avian Influenza (HPAI) intratracheal and intranasal challenge in a ferret model. Six groups of 6 ferrets were intranasally vaccinated twice, 21 days apart,...

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Detalles Bibliográficos
Autores principales: Mann, Alex J., Noulin, Nicolas, Catchpole, Andrew, Stittelaar, Koert J., de Waal, Leon, Veldhuis Kroeze, Edwin J. B., Hinchcliffe, Michael, Smith, Alan, Montomoli, Emanuele, Piccirella, Simona, Osterhaus, Albert D. M. E., Knight, Alastair, Oxford, John S., Lapini, Giulia, Cox, Rebecca, Lambkin-Williams, Rob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4029577/
https://www.ncbi.nlm.nih.gov/pubmed/24850536
http://dx.doi.org/10.1371/journal.pone.0093761

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