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Characterization of CurcuEmulsomes: nanoformulation for enhanced solubility and delivery of curcumin

BACKGROUND: Curcumin is a polyphenolic compound isolated from the rhizomes of the plant Curcuma longa and shows intrinsic anti-cancer properties. Its medical use remains limited due to its extremely low water solubility and bioavailability. Addressing this problem, drug delivery systems accompanied...

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Autores principales: Ucisik, Mehmet H, Küpcü, Seta, Schuster, Bernhard, Sleytr, Uwe B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4029586/
https://www.ncbi.nlm.nih.gov/pubmed/24314310
http://dx.doi.org/10.1186/1477-3155-11-37
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author Ucisik, Mehmet H
Küpcü, Seta
Schuster, Bernhard
Sleytr, Uwe B
author_facet Ucisik, Mehmet H
Küpcü, Seta
Schuster, Bernhard
Sleytr, Uwe B
author_sort Ucisik, Mehmet H
collection PubMed
description BACKGROUND: Curcumin is a polyphenolic compound isolated from the rhizomes of the plant Curcuma longa and shows intrinsic anti-cancer properties. Its medical use remains limited due to its extremely low water solubility and bioavailability. Addressing this problem, drug delivery systems accompanied by nanoparticle technology have emerged. The present study introduces a novel nanocarrier system, so-called CurcuEmulsomes, where curcumin is encapsulated inside the solid core of emulsomes. RESULTS: CurcuEmulsomes are spherical solid nanoparticles with an average size of 286 nm and a zeta potential of 37 mV. Encapsulation increases the bioavailability of curcumin by up to 10,000 fold corresponding to a concentration of 0.11 mg/mL. Uptaken by HepG2 human liver carcinoma cell line, CurcuEmulsomes show a significantly prolonged biological activity and demonstrated therapeutic efficacy comparable to free curcumin against HepG2 in vitro - with a delay in response, as assessed by cell viability, apoptosis and cell cycle studies. The delay is attributed to the solid character of the nanocarrier prolonging the release of curcumin inside the HepG2 cells. CONCLUSIONS: Incorporation of curcumin into emulsomes results in water-soluble and stable CurcuEmulsome nanoformulations. CurcuEmulsomes do not only successfully facilitate the delivery of curcumin into the cell in vitro, but also enable curcumin to reach its effective concentrations inside the cell. The enhanced solubility of curcumin and the promising in vitro efficacy of CurcuEmulsomes highlight the potential of the system for the delivery of lipophilic drugs. Moreover, high degree of compatibility, prolonged release profile and tailoring properties feature CurcuEmulsomes for further therapeutic applications in vivo.
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spelling pubmed-40295862014-05-22 Characterization of CurcuEmulsomes: nanoformulation for enhanced solubility and delivery of curcumin Ucisik, Mehmet H Küpcü, Seta Schuster, Bernhard Sleytr, Uwe B J Nanobiotechnology Research BACKGROUND: Curcumin is a polyphenolic compound isolated from the rhizomes of the plant Curcuma longa and shows intrinsic anti-cancer properties. Its medical use remains limited due to its extremely low water solubility and bioavailability. Addressing this problem, drug delivery systems accompanied by nanoparticle technology have emerged. The present study introduces a novel nanocarrier system, so-called CurcuEmulsomes, where curcumin is encapsulated inside the solid core of emulsomes. RESULTS: CurcuEmulsomes are spherical solid nanoparticles with an average size of 286 nm and a zeta potential of 37 mV. Encapsulation increases the bioavailability of curcumin by up to 10,000 fold corresponding to a concentration of 0.11 mg/mL. Uptaken by HepG2 human liver carcinoma cell line, CurcuEmulsomes show a significantly prolonged biological activity and demonstrated therapeutic efficacy comparable to free curcumin against HepG2 in vitro - with a delay in response, as assessed by cell viability, apoptosis and cell cycle studies. The delay is attributed to the solid character of the nanocarrier prolonging the release of curcumin inside the HepG2 cells. CONCLUSIONS: Incorporation of curcumin into emulsomes results in water-soluble and stable CurcuEmulsome nanoformulations. CurcuEmulsomes do not only successfully facilitate the delivery of curcumin into the cell in vitro, but also enable curcumin to reach its effective concentrations inside the cell. The enhanced solubility of curcumin and the promising in vitro efficacy of CurcuEmulsomes highlight the potential of the system for the delivery of lipophilic drugs. Moreover, high degree of compatibility, prolonged release profile and tailoring properties feature CurcuEmulsomes for further therapeutic applications in vivo. BioMed Central 2013-12-06 /pmc/articles/PMC4029586/ /pubmed/24314310 http://dx.doi.org/10.1186/1477-3155-11-37 Text en Copyright © 2013 Ucisik et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Ucisik, Mehmet H
Küpcü, Seta
Schuster, Bernhard
Sleytr, Uwe B
Characterization of CurcuEmulsomes: nanoformulation for enhanced solubility and delivery of curcumin
title Characterization of CurcuEmulsomes: nanoformulation for enhanced solubility and delivery of curcumin
title_full Characterization of CurcuEmulsomes: nanoformulation for enhanced solubility and delivery of curcumin
title_fullStr Characterization of CurcuEmulsomes: nanoformulation for enhanced solubility and delivery of curcumin
title_full_unstemmed Characterization of CurcuEmulsomes: nanoformulation for enhanced solubility and delivery of curcumin
title_short Characterization of CurcuEmulsomes: nanoformulation for enhanced solubility and delivery of curcumin
title_sort characterization of curcuemulsomes: nanoformulation for enhanced solubility and delivery of curcumin
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4029586/
https://www.ncbi.nlm.nih.gov/pubmed/24314310
http://dx.doi.org/10.1186/1477-3155-11-37
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