Does Metformin affect ER, PR, IGF-1R, β-catenin and PAX-2 expression in women with diabetes mellitus and endometrial cancer?

OBJECTIVE: Diabetes mellitus, as a risk factor for endometrial cancer (EC), causes an increase in insulin and IGF-1 concentrations in the blood serum. The increase in insulin and IGF-1 are considered mitogenic factors contributory to cancer development. Studies suggest that metformin has preventive...

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Detalles Bibliográficos
Autores principales: Markowska, Anna, Pawałowska, Monika, Filas, Violetta, Korski, Konstanty, Gryboś, Marian, Sajdak, Stefan, Olejek, Anita, Bednarek, Wiesława, Śpiewankiewicz, Beata, Lubin, Jolanta, Markowska, Janina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4029605/
https://www.ncbi.nlm.nih.gov/pubmed/24308813
http://dx.doi.org/10.1186/1758-5996-5-76

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