Safety and Pharmacokinetics of Escalating Doses of Human Recombinant Nerve Growth Factor Eye Drops in a Double-Masked, Randomized Clinical Trial

BACKGROUND AND OBJECTIVES: Nerve growth factor (NGF) is a neurotrophin with therapeutic possibilities that extend from the nervous system to the eye. We tested the safety, maximal tolerated dose, pharmacokinetics, and antigenicity of a novel human recombinant NGF (rhNGF) eye-drop formulation in a ph...

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Detalles Bibliográficos
Autores principales: Ferrari, Mauro P., Mantelli, Flavio, Sacchetti, Marta, Antonangeli, Maria Irene, Cattani, Franca, D’Anniballe, Gaetano, Sinigaglia, Francesco, Ruffini, Pier Adelchi, Lambiase, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2013
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030100/
https://www.ncbi.nlm.nih.gov/pubmed/24327173
http://dx.doi.org/10.1007/s40259-013-0079-5

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