Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity

Patients with established type 2 diabetes display both β-cell dysfunction and insulin resistance. To define fundamental processes leading to the diabetic state, we examined the relationship between type 2 diabetes risk variants at 37 established susceptibility loci, and indices of proinsulin process...

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Detalles Bibliográficos
Autores principales: Dimas, Antigone S., Lagou, Vasiliki, Barker, Adam, Knowles, Joshua W., Mägi, Reedik, Hivert, Marie-France, Benazzo, Andrea, Rybin, Denis, Jackson, Anne U., Stringham, Heather M., Song, Ci, Fischer-Rosinsky, Antje, Boesgaard, Trine Welløv, Grarup, Niels, Abbasi, Fahim A., Assimes, Themistocles L., Hao, Ke, Yang, Xia, Lecoeur, Cécile, Barroso, Inês, Bonnycastle, Lori L., Böttcher, Yvonne, Bumpstead, Suzannah, Chines, Peter S., Erdos, Michael R., Graessler, Jurgen, Kovacs, Peter, Morken, Mario A., Narisu, Narisu, Payne, Felicity, Stancakova, Alena, Swift, Amy J., Tönjes, Anke, Bornstein, Stefan R., Cauchi, Stéphane, Froguel, Philippe, Meyre, David, Schwarz, Peter E.H., Häring, Hans-Ulrich, Smith, Ulf, Boehnke, Michael, Bergman, Richard N., Collins, Francis S., Mohlke, Karen L., Tuomilehto, Jaakko, Quertemous, Thomas, Lind, Lars, Hansen, Torben, Pedersen, Oluf, Walker, Mark, Pfeiffer, Andreas F.H., Spranger, Joachim, Stumvoll, Michael, Meigs, James B., Wareham, Nicholas J., Kuusisto, Johanna, Laakso, Markku, Langenberg, Claudia, Dupuis, Josée, Watanabe, Richard M., Florez, Jose C., Ingelsson, Erik, McCarthy, Mark I., Prokopenko, Inga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2014
Materias:
Genetics/Genomes/Proteomics/Metabolomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030103/
https://www.ncbi.nlm.nih.gov/pubmed/24296717
http://dx.doi.org/10.2337/db13-0949

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