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Circadian Misalignment Augments Markers of Insulin Resistance and Inflammation, Independently of Sleep Loss
Shift workers, who are exposed to irregular sleep schedules resulting in sleep deprivation and misalignment of circadian rhythms, have an increased risk of diabetes relative to day workers. In healthy adults, sleep restriction without circadian misalignment promotes insulin resistance. To determine...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Diabetes Association
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030107/ https://www.ncbi.nlm.nih.gov/pubmed/24458353 http://dx.doi.org/10.2337/db13-1546 |
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author | Leproult, Rachel Holmbäck, Ulf Van Cauter, Eve |
author_facet | Leproult, Rachel Holmbäck, Ulf Van Cauter, Eve |
author_sort | Leproult, Rachel |
collection | PubMed |
description | Shift workers, who are exposed to irregular sleep schedules resulting in sleep deprivation and misalignment of circadian rhythms, have an increased risk of diabetes relative to day workers. In healthy adults, sleep restriction without circadian misalignment promotes insulin resistance. To determine whether the misalignment of circadian rhythms that typically occurs in shift work involves intrinsic adverse metabolic effects independently of sleep loss, a parallel group design was used to study 26 healthy adults. Both interventions involved 3 inpatient days with 10-h bedtimes, followed by 8 inpatient days of sleep restriction to 5 h with fixed nocturnal bedtimes (circadian alignment) or with bedtimes delayed by 8.5 h on 4 of the 8 days (circadian misalignment). Daily total sleep time (SD) during the intervention was nearly identical in the aligned and misaligned conditions (4 h 48 min [5 min] vs. 4 h 45 min [6 min]). In both groups, insulin sensitivity (SI) significantly decreased after sleep restriction, without a compensatory increase in insulin secretion, and inflammation increased. In male participants exposed to circadian misalignment, the reduction in SI and the increase in inflammation both doubled compared with those who maintained regular nocturnal bedtimes. Circadian misalignment that occurs in shift work may increase diabetes risk and inflammation, independently of sleep loss. |
format | Online Article Text |
id | pubmed-4030107 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | American Diabetes Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-40301072015-06-01 Circadian Misalignment Augments Markers of Insulin Resistance and Inflammation, Independently of Sleep Loss Leproult, Rachel Holmbäck, Ulf Van Cauter, Eve Diabetes Metabolism Shift workers, who are exposed to irregular sleep schedules resulting in sleep deprivation and misalignment of circadian rhythms, have an increased risk of diabetes relative to day workers. In healthy adults, sleep restriction without circadian misalignment promotes insulin resistance. To determine whether the misalignment of circadian rhythms that typically occurs in shift work involves intrinsic adverse metabolic effects independently of sleep loss, a parallel group design was used to study 26 healthy adults. Both interventions involved 3 inpatient days with 10-h bedtimes, followed by 8 inpatient days of sleep restriction to 5 h with fixed nocturnal bedtimes (circadian alignment) or with bedtimes delayed by 8.5 h on 4 of the 8 days (circadian misalignment). Daily total sleep time (SD) during the intervention was nearly identical in the aligned and misaligned conditions (4 h 48 min [5 min] vs. 4 h 45 min [6 min]). In both groups, insulin sensitivity (SI) significantly decreased after sleep restriction, without a compensatory increase in insulin secretion, and inflammation increased. In male participants exposed to circadian misalignment, the reduction in SI and the increase in inflammation both doubled compared with those who maintained regular nocturnal bedtimes. Circadian misalignment that occurs in shift work may increase diabetes risk and inflammation, independently of sleep loss. American Diabetes Association 2014-06 2014-05-15 /pmc/articles/PMC4030107/ /pubmed/24458353 http://dx.doi.org/10.2337/db13-1546 Text en © 2014 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details. |
spellingShingle | Metabolism Leproult, Rachel Holmbäck, Ulf Van Cauter, Eve Circadian Misalignment Augments Markers of Insulin Resistance and Inflammation, Independently of Sleep Loss |
title | Circadian Misalignment Augments Markers of Insulin Resistance and Inflammation, Independently of Sleep Loss |
title_full | Circadian Misalignment Augments Markers of Insulin Resistance and Inflammation, Independently of Sleep Loss |
title_fullStr | Circadian Misalignment Augments Markers of Insulin Resistance and Inflammation, Independently of Sleep Loss |
title_full_unstemmed | Circadian Misalignment Augments Markers of Insulin Resistance and Inflammation, Independently of Sleep Loss |
title_short | Circadian Misalignment Augments Markers of Insulin Resistance and Inflammation, Independently of Sleep Loss |
title_sort | circadian misalignment augments markers of insulin resistance and inflammation, independently of sleep loss |
topic | Metabolism |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030107/ https://www.ncbi.nlm.nih.gov/pubmed/24458353 http://dx.doi.org/10.2337/db13-1546 |
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