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Circadian Misalignment Augments Markers of Insulin Resistance and Inflammation, Independently of Sleep Loss

Shift workers, who are exposed to irregular sleep schedules resulting in sleep deprivation and misalignment of circadian rhythms, have an increased risk of diabetes relative to day workers. In healthy adults, sleep restriction without circadian misalignment promotes insulin resistance. To determine...

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Detalles Bibliográficos
Autores principales: Leproult, Rachel, Holmbäck, Ulf, Van Cauter, Eve
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030107/
https://www.ncbi.nlm.nih.gov/pubmed/24458353
http://dx.doi.org/10.2337/db13-1546
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author Leproult, Rachel
Holmbäck, Ulf
Van Cauter, Eve
author_facet Leproult, Rachel
Holmbäck, Ulf
Van Cauter, Eve
author_sort Leproult, Rachel
collection PubMed
description Shift workers, who are exposed to irregular sleep schedules resulting in sleep deprivation and misalignment of circadian rhythms, have an increased risk of diabetes relative to day workers. In healthy adults, sleep restriction without circadian misalignment promotes insulin resistance. To determine whether the misalignment of circadian rhythms that typically occurs in shift work involves intrinsic adverse metabolic effects independently of sleep loss, a parallel group design was used to study 26 healthy adults. Both interventions involved 3 inpatient days with 10-h bedtimes, followed by 8 inpatient days of sleep restriction to 5 h with fixed nocturnal bedtimes (circadian alignment) or with bedtimes delayed by 8.5 h on 4 of the 8 days (circadian misalignment). Daily total sleep time (SD) during the intervention was nearly identical in the aligned and misaligned conditions (4 h 48 min [5 min] vs. 4 h 45 min [6 min]). In both groups, insulin sensitivity (SI) significantly decreased after sleep restriction, without a compensatory increase in insulin secretion, and inflammation increased. In male participants exposed to circadian misalignment, the reduction in SI and the increase in inflammation both doubled compared with those who maintained regular nocturnal bedtimes. Circadian misalignment that occurs in shift work may increase diabetes risk and inflammation, independently of sleep loss.
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spelling pubmed-40301072015-06-01 Circadian Misalignment Augments Markers of Insulin Resistance and Inflammation, Independently of Sleep Loss Leproult, Rachel Holmbäck, Ulf Van Cauter, Eve Diabetes Metabolism Shift workers, who are exposed to irregular sleep schedules resulting in sleep deprivation and misalignment of circadian rhythms, have an increased risk of diabetes relative to day workers. In healthy adults, sleep restriction without circadian misalignment promotes insulin resistance. To determine whether the misalignment of circadian rhythms that typically occurs in shift work involves intrinsic adverse metabolic effects independently of sleep loss, a parallel group design was used to study 26 healthy adults. Both interventions involved 3 inpatient days with 10-h bedtimes, followed by 8 inpatient days of sleep restriction to 5 h with fixed nocturnal bedtimes (circadian alignment) or with bedtimes delayed by 8.5 h on 4 of the 8 days (circadian misalignment). Daily total sleep time (SD) during the intervention was nearly identical in the aligned and misaligned conditions (4 h 48 min [5 min] vs. 4 h 45 min [6 min]). In both groups, insulin sensitivity (SI) significantly decreased after sleep restriction, without a compensatory increase in insulin secretion, and inflammation increased. In male participants exposed to circadian misalignment, the reduction in SI and the increase in inflammation both doubled compared with those who maintained regular nocturnal bedtimes. Circadian misalignment that occurs in shift work may increase diabetes risk and inflammation, independently of sleep loss. American Diabetes Association 2014-06 2014-05-15 /pmc/articles/PMC4030107/ /pubmed/24458353 http://dx.doi.org/10.2337/db13-1546 Text en © 2014 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.
spellingShingle Metabolism
Leproult, Rachel
Holmbäck, Ulf
Van Cauter, Eve
Circadian Misalignment Augments Markers of Insulin Resistance and Inflammation, Independently of Sleep Loss
title Circadian Misalignment Augments Markers of Insulin Resistance and Inflammation, Independently of Sleep Loss
title_full Circadian Misalignment Augments Markers of Insulin Resistance and Inflammation, Independently of Sleep Loss
title_fullStr Circadian Misalignment Augments Markers of Insulin Resistance and Inflammation, Independently of Sleep Loss
title_full_unstemmed Circadian Misalignment Augments Markers of Insulin Resistance and Inflammation, Independently of Sleep Loss
title_short Circadian Misalignment Augments Markers of Insulin Resistance and Inflammation, Independently of Sleep Loss
title_sort circadian misalignment augments markers of insulin resistance and inflammation, independently of sleep loss
topic Metabolism
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030107/
https://www.ncbi.nlm.nih.gov/pubmed/24458353
http://dx.doi.org/10.2337/db13-1546
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