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Evidence for a Causal Relationship Between Early Exocrine Pancreatic Disease and Cystic Fibrosis–Related Diabetes: A Mendelian Randomization Study

Circulating immunoreactive trypsinogen (IRT), a biomarker of exocrine pancreatic disease in cystic fibrosis (CF), is elevated in most CF newborns. In those with severe CF transmembrane conductance regulator (CFTR) genotypes, IRT declines rapidly in the first years of life, reflecting progressive pan...

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Detalles Bibliográficos
Autores principales:	Soave, David, Miller, Melissa R., Keenan, Katherine, Li, Weili, Gong, Jiafen, Ip, Wan, Accurso, Frank, Sun, Lei, Rommens, Johanna M., Sontag, Marci, Durie, Peter R., Strug, Lisa J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2014
Materias:	Pathophysiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030111/ https://www.ncbi.nlm.nih.gov/pubmed/24550193 http://dx.doi.org/10.2337/db13-1464

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