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Perspectives of a scrapie resistance breeding scheme targeting Q211, S146 and K222 caprine PRNP alleles in Greek goats

The present study investigates the potential use of the scrapie-protective Q211 S146 and K222 caprine PRNP alleles as targets for selective breeding in Greek goats. Genotyping data from a high number of healthy goats with special emphasis on bucks, revealed high frequencies of these alleles, while t...

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Autores principales: Kanata, Eirini, Humphreys-Panagiotidis, Cynthia, Giadinis, Nektarios D, Papaioannou, Nikolaos, Arsenakis, Minas, Sklaviadis, Theodoros
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030296/
https://www.ncbi.nlm.nih.gov/pubmed/24717012
http://dx.doi.org/10.1186/1297-9716-45-43
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author Kanata, Eirini
Humphreys-Panagiotidis, Cynthia
Giadinis, Nektarios D
Papaioannou, Nikolaos
Arsenakis, Minas
Sklaviadis, Theodoros
author_facet Kanata, Eirini
Humphreys-Panagiotidis, Cynthia
Giadinis, Nektarios D
Papaioannou, Nikolaos
Arsenakis, Minas
Sklaviadis, Theodoros
author_sort Kanata, Eirini
collection PubMed
description The present study investigates the potential use of the scrapie-protective Q211 S146 and K222 caprine PRNP alleles as targets for selective breeding in Greek goats. Genotyping data from a high number of healthy goats with special emphasis on bucks, revealed high frequencies of these alleles, while the estimated probabilities of disease occurrence in animals carrying these alleles were low, suggesting that they can be used for selection. Greek goats represent one of the largest populations in Europe. Thus, the considerations presented here are an example of the expected effect of such a scheme on scrapie occurrence and on stakeholders.
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spelling pubmed-40302962014-05-23 Perspectives of a scrapie resistance breeding scheme targeting Q211, S146 and K222 caprine PRNP alleles in Greek goats Kanata, Eirini Humphreys-Panagiotidis, Cynthia Giadinis, Nektarios D Papaioannou, Nikolaos Arsenakis, Minas Sklaviadis, Theodoros Vet Res Short Report The present study investigates the potential use of the scrapie-protective Q211 S146 and K222 caprine PRNP alleles as targets for selective breeding in Greek goats. Genotyping data from a high number of healthy goats with special emphasis on bucks, revealed high frequencies of these alleles, while the estimated probabilities of disease occurrence in animals carrying these alleles were low, suggesting that they can be used for selection. Greek goats represent one of the largest populations in Europe. Thus, the considerations presented here are an example of the expected effect of such a scheme on scrapie occurrence and on stakeholders. BioMed Central 2014 2014-04-09 /pmc/articles/PMC4030296/ /pubmed/24717012 http://dx.doi.org/10.1186/1297-9716-45-43 Text en Copyright © 2014 Kanata et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Short Report
Kanata, Eirini
Humphreys-Panagiotidis, Cynthia
Giadinis, Nektarios D
Papaioannou, Nikolaos
Arsenakis, Minas
Sklaviadis, Theodoros
Perspectives of a scrapie resistance breeding scheme targeting Q211, S146 and K222 caprine PRNP alleles in Greek goats
title Perspectives of a scrapie resistance breeding scheme targeting Q211, S146 and K222 caprine PRNP alleles in Greek goats
title_full Perspectives of a scrapie resistance breeding scheme targeting Q211, S146 and K222 caprine PRNP alleles in Greek goats
title_fullStr Perspectives of a scrapie resistance breeding scheme targeting Q211, S146 and K222 caprine PRNP alleles in Greek goats
title_full_unstemmed Perspectives of a scrapie resistance breeding scheme targeting Q211, S146 and K222 caprine PRNP alleles in Greek goats
title_short Perspectives of a scrapie resistance breeding scheme targeting Q211, S146 and K222 caprine PRNP alleles in Greek goats
title_sort perspectives of a scrapie resistance breeding scheme targeting q211, s146 and k222 caprine prnp alleles in greek goats
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030296/
https://www.ncbi.nlm.nih.gov/pubmed/24717012
http://dx.doi.org/10.1186/1297-9716-45-43
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