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Loss of serum IGF-I input to the brain as an early biomarker of disease onset in Alzheimer mice

Circulating insulin-like growth factor I (IGF-I) enters the brain and promotes clearance of amyloid peptides known to accumulate in Alzheimer's disease (AD) brains. Both patients and mouse models of AD show decreased level of circulating IGF-I enter the brain as evidenced by a lower ratio of ce...

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Detalles Bibliográficos
Autores principales:	Trueba-Sáiz, A, Cavada, C, Fernandez, A M, Leon, T, González, D A, Fortea Ormaechea, J, Lleó, A, Del Ser, T, Nuñez, A, Torres-Aleman, I
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2013
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030321/ https://www.ncbi.nlm.nih.gov/pubmed/24301648 http://dx.doi.org/10.1038/tp.2013.102

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