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Metal-Free cAMP-Dependent Protein Kinase Can Catalyze Phosphoryl Transfer
[Image: see text] X-ray structures of several ternary product complexes of the catalytic subunit of cAMP-dependent protein kinase (PKAc) have been determined with no bound metal ions and with Na(+) or K(+) coordinated at two metal-binding sites. The metal-free PKAc and the enzyme with alkali metals...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American
Chemical Society
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030786/ https://www.ncbi.nlm.nih.gov/pubmed/24786636 http://dx.doi.org/10.1021/bi5000965 |