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Metal-Free cAMP-Dependent Protein Kinase Can Catalyze Phosphoryl Transfer

[Image: see text] X-ray structures of several ternary product complexes of the catalytic subunit of cAMP-dependent protein kinase (PKAc) have been determined with no bound metal ions and with Na(+) or K(+) coordinated at two metal-binding sites. The metal-free PKAc and the enzyme with alkali metals...

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Detalles Bibliográficos
Autores principales:	Gerlits, Oksana, Das, Amit, Keshwani, Malik M., Taylor, Susan, Waltman, Mary Jo, Langan, Paul, Heller, William T., Kovalevsky, Andrey
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030786/ https://www.ncbi.nlm.nih.gov/pubmed/24786636 http://dx.doi.org/10.1021/bi5000965

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