Discovery of the First N-Hydroxycinnamamide-Based Histone Deacetylase 1/3 Dual Inhibitors with Potent Oral Antitumor Activity

[Image: see text] In our previous study, we designed and synthesized a novel series of N-hydroxycinnamamide-based HDAC inhibitors (HDACIs), among which the representative compound 14a exhibited promising HDACs inhibition and antitumor activity. In this current study, we report the development of a m...

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Detalles Bibliográficos
Autores principales: Li, Xiaoyang, Inks, Elizabeth S., Li, Xiaoguang, Hou, Jinning, Chou, C. James, Zhang, Jian, Jiang, Yuqi, Zhang, Yingjie, Xu, Wenfang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030833/
https://www.ncbi.nlm.nih.gov/pubmed/24694055
http://dx.doi.org/10.1021/jm401877m

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030833/
https://www.ncbi.nlm.nih.gov/pubmed/24694055
http://dx.doi.org/10.1021/jm401877m

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