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Leucine-Rich Repeat (LRR) Domains Containing Intervening Motifs in Plants
LRRs (leucine rich repeats) are present in over 14,000 proteins. Non-LRR, island regions (IRs) interrupting LRRs are widely distributed. The present article reviews 19 families of LRR proteins having non-LRR IRs (LRR@IR proteins) from various plant species. The LRR@IR proteins are LRR-containing rec...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030839/ https://www.ncbi.nlm.nih.gov/pubmed/24970139 http://dx.doi.org/10.3390/biom2020288 |
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author | Matsushima, Norio Miyashita, Hiroki |
author_facet | Matsushima, Norio Miyashita, Hiroki |
author_sort | Matsushima, Norio |
collection | PubMed |
description | LRRs (leucine rich repeats) are present in over 14,000 proteins. Non-LRR, island regions (IRs) interrupting LRRs are widely distributed. The present article reviews 19 families of LRR proteins having non-LRR IRs (LRR@IR proteins) from various plant species. The LRR@IR proteins are LRR-containing receptor-like kinases (LRR-RLKs), LRR-containing receptor-like proteins (LRR-RLPs), TONSOKU/BRUSHY1, and MJK13.7; the LRR-RLKs are homologs of TMK1/Rhg4, BRI1, PSKR, PSYR1, Arabidopsis At1g74360, and RPK2, while the LRR-RLPs are those of Cf-9/Cf-4, Cf-2/Cf-5, Ve, HcrVf, RPP27, EIX1, clavata 2, fascinated ear2, RLP2, rice Os10g0479700, and putative soybean disease resistance protein. The LRRs are intersected by single, non-LRR IRs; only the RPK2 homologs have two IRs. In most of the LRR-RLKs and LRR-RLPs, the number of repeat units in the preceding LRR block (N(1)) is greater than the number of the following block (N(2)); N(1) » N(2 ) in which N(1) is variable in the homologs of individual families, while N(2) is highly conserved. The five families of the LRR-RLKs except for the RPK2 family show N(1) = 8 − 18 and N(2) = 3 − 5. The nine families of the LRR-RLPs show N(1) = 12 − 33 and N(2) = 4; while N(1) = 6 and N(2) = 4 for the rice Os10g0479700 family and the N(1) = 4 − 28 and N(2) = 4 for the soybean protein family. The rule of N(1) » N(2) might play a common, significant role in ligand interaction, dimerization, and/or signal transduction of the LRR-RLKs and the LRR-RLPs. The structure and evolution of the LRR domains with non-LRR IRs and their proteins are also discussed. |
format | Online Article Text |
id | pubmed-4030839 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-40308392014-06-24 Leucine-Rich Repeat (LRR) Domains Containing Intervening Motifs in Plants Matsushima, Norio Miyashita, Hiroki Biomolecules Review LRRs (leucine rich repeats) are present in over 14,000 proteins. Non-LRR, island regions (IRs) interrupting LRRs are widely distributed. The present article reviews 19 families of LRR proteins having non-LRR IRs (LRR@IR proteins) from various plant species. The LRR@IR proteins are LRR-containing receptor-like kinases (LRR-RLKs), LRR-containing receptor-like proteins (LRR-RLPs), TONSOKU/BRUSHY1, and MJK13.7; the LRR-RLKs are homologs of TMK1/Rhg4, BRI1, PSKR, PSYR1, Arabidopsis At1g74360, and RPK2, while the LRR-RLPs are those of Cf-9/Cf-4, Cf-2/Cf-5, Ve, HcrVf, RPP27, EIX1, clavata 2, fascinated ear2, RLP2, rice Os10g0479700, and putative soybean disease resistance protein. The LRRs are intersected by single, non-LRR IRs; only the RPK2 homologs have two IRs. In most of the LRR-RLKs and LRR-RLPs, the number of repeat units in the preceding LRR block (N(1)) is greater than the number of the following block (N(2)); N(1) » N(2 ) in which N(1) is variable in the homologs of individual families, while N(2) is highly conserved. The five families of the LRR-RLKs except for the RPK2 family show N(1) = 8 − 18 and N(2) = 3 − 5. The nine families of the LRR-RLPs show N(1) = 12 − 33 and N(2) = 4; while N(1) = 6 and N(2) = 4 for the rice Os10g0479700 family and the N(1) = 4 − 28 and N(2) = 4 for the soybean protein family. The rule of N(1) » N(2) might play a common, significant role in ligand interaction, dimerization, and/or signal transduction of the LRR-RLKs and the LRR-RLPs. The structure and evolution of the LRR domains with non-LRR IRs and their proteins are also discussed. MDPI 2012-06-22 /pmc/articles/PMC4030839/ /pubmed/24970139 http://dx.doi.org/10.3390/biom2020288 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Matsushima, Norio Miyashita, Hiroki Leucine-Rich Repeat (LRR) Domains Containing Intervening Motifs in Plants |
title | Leucine-Rich Repeat (LRR) Domains Containing Intervening Motifs in Plants |
title_full | Leucine-Rich Repeat (LRR) Domains Containing Intervening Motifs in Plants |
title_fullStr | Leucine-Rich Repeat (LRR) Domains Containing Intervening Motifs in Plants |
title_full_unstemmed | Leucine-Rich Repeat (LRR) Domains Containing Intervening Motifs in Plants |
title_short | Leucine-Rich Repeat (LRR) Domains Containing Intervening Motifs in Plants |
title_sort | leucine-rich repeat (lrr) domains containing intervening motifs in plants |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030839/ https://www.ncbi.nlm.nih.gov/pubmed/24970139 http://dx.doi.org/10.3390/biom2020288 |
work_keys_str_mv | AT matsushimanorio leucinerichrepeatlrrdomainscontaininginterveningmotifsinplants AT miyashitahiroki leucinerichrepeatlrrdomainscontaininginterveningmotifsinplants |