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Sialyl-Tn in Cancer: (How) Did We Miss the Target?

Sialyl-Tn antigen (STn) is a short O-glycan containing a sialic acid residue α2,6-linked to GalNAcα-O-Ser/Thr. The biosynthesis of STn is mediated by a specific sialyltransferase termed ST6GalNAc I, which competes with O-glycans elongating glycosyltransferases and prevents cancer cells from exhibiti...

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Detalles Bibliográficos
Autores principales:	Julien, Sylvain, Videira, Paula A., Delannoy, Philippe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2012
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030860/ https://www.ncbi.nlm.nih.gov/pubmed/24970145 http://dx.doi.org/10.3390/biom2040435

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