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Functional Aspects of PARP1 in DNA Repair and Transcription

Poly (ADP-ribose) polymerase 1 (PARP1) is an ADP-ribosylating enzyme essential for initiating various forms of DNA repair. Inhibiting its enzyme activity with small molecules thus achieves synthetic lethality by preventing unwanted DNA repair in the treatment of cancers. Through enzyme-dependent chr...

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Detalles Bibliográficos
Autores principales:	Ko, Hui Ling, Ren, Ee Chee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2012
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030864/ https://www.ncbi.nlm.nih.gov/pubmed/24970148 http://dx.doi.org/10.3390/biom2040524

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