Conformational Ensembles of an Intrinsically Disordered Protein pKID with and without a KIX Domain in Explicit Solvent Investigated by All-Atom Multicanonical Molecular Dynamics

The phosphorylated kinase-inducible activation domain (pKID) adopts a helix–loop–helix structure upon binding to its partner KIX, although it is unstructured in the unbound state. The N-terminal and C-terminal regions of pKID, which adopt helices in the complex, are called, respectively, α(A) and α(...

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Detalles Bibliográficos
Autores principales: Umezawa, Koji, Ikebe, Jinzen, Takano, Mitsunori, Nakamura, Haruki, Higo, Junichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030872/
https://www.ncbi.nlm.nih.gov/pubmed/24970129
http://dx.doi.org/10.3390/biom2010104

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030872/
https://www.ncbi.nlm.nih.gov/pubmed/24970129
http://dx.doi.org/10.3390/biom2010104

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