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Mechanotransduction: Tuning Stem Cells Fate

It is a general concern that the success of regenerative medicine-based applications is based on the ability to recapitulate the molecular events that allow stem cells to repair the damaged tissue/organ. To this end biomaterials are designed to display properties that, in a precise and physiological...

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Detalles Bibliográficos
Autores principales: D'Angelo, Francesco, Tiribuzi, Roberto, Armentano, Ilaria, Kenny, Josè Maria, Martino, Sabata, Orlacchio, Aldo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030896/
https://www.ncbi.nlm.nih.gov/pubmed/24956164
http://dx.doi.org/10.3390/jfb2020067
Descripción
Sumario:It is a general concern that the success of regenerative medicine-based applications is based on the ability to recapitulate the molecular events that allow stem cells to repair the damaged tissue/organ. To this end biomaterials are designed to display properties that, in a precise and physiological-like fashion, could drive stem cell fate both in vitro and in vivo. The rationale is that stem cells are highly sensitive to forces and that they may convert mechanical stimuli into a chemical response. In this review, we describe novelties on stem cells and biomaterials interactions with more focus on the implication of the mechanical stimulation named mechanotransduction.