Poly(2-hydroxyethyl methacrylate)-quercetin Conjugate as Biomaterial in Ophthalmology: An “ab initio” Study

A novel polymeric material with antioxidant properties and suitable for ophthalmic application was synthesized by free radical grafting reaction between 2-hydroxyethyl methacrylate and quercetin. The presence of quercetin in the polymeric chain was confirmed by FT-IR and UV-Vis analyses, while an es...

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Autores principales: Curcio, Manuela, Cirillo, Giuseppe, Parisi, Ortensia Ilaria, Iemma, Francesca, Spizzirri, Umile Gianfranco, Altimari, Ilaria, Picci, Nevio, Puoci, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030902/
https://www.ncbi.nlm.nih.gov/pubmed/24956059
http://dx.doi.org/10.3390/jfb2010001
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author Curcio, Manuela
Cirillo, Giuseppe
Parisi, Ortensia Ilaria
Iemma, Francesca
Spizzirri, Umile Gianfranco
Altimari, Ilaria
Picci, Nevio
Puoci, Francesco
author_facet Curcio, Manuela
Cirillo, Giuseppe
Parisi, Ortensia Ilaria
Iemma, Francesca
Spizzirri, Umile Gianfranco
Altimari, Ilaria
Picci, Nevio
Puoci, Francesco
author_sort Curcio, Manuela
collection PubMed
description A novel polymeric material with antioxidant properties and suitable for ophthalmic application was synthesized by free radical grafting reaction between 2-hydroxyethyl methacrylate and quercetin. The presence of quercetin in the polymeric chain was confirmed by FT-IR and UV-Vis analyses, while an estimation of the amount of quercetin bound per gram of polymer was obtained by the Folin-Ciocalteu assay. The conjugate shows high biocompatibility (HET-CAM assay) and antioxidant and anti-inflammatory properties which were extensively investigated by specific in vitro tests.
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spelling pubmed-40309022014-06-12 Poly(2-hydroxyethyl methacrylate)-quercetin Conjugate as Biomaterial in Ophthalmology: An “ab initio” Study Curcio, Manuela Cirillo, Giuseppe Parisi, Ortensia Ilaria Iemma, Francesca Spizzirri, Umile Gianfranco Altimari, Ilaria Picci, Nevio Puoci, Francesco J Funct Biomater Article A novel polymeric material with antioxidant properties and suitable for ophthalmic application was synthesized by free radical grafting reaction between 2-hydroxyethyl methacrylate and quercetin. The presence of quercetin in the polymeric chain was confirmed by FT-IR and UV-Vis analyses, while an estimation of the amount of quercetin bound per gram of polymer was obtained by the Folin-Ciocalteu assay. The conjugate shows high biocompatibility (HET-CAM assay) and antioxidant and anti-inflammatory properties which were extensively investigated by specific in vitro tests. MDPI 2011-01-27 /pmc/articles/PMC4030902/ /pubmed/24956059 http://dx.doi.org/10.3390/jfb2010001 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Curcio, Manuela
Cirillo, Giuseppe
Parisi, Ortensia Ilaria
Iemma, Francesca
Spizzirri, Umile Gianfranco
Altimari, Ilaria
Picci, Nevio
Puoci, Francesco
Poly(2-hydroxyethyl methacrylate)-quercetin Conjugate as Biomaterial in Ophthalmology: An “ab initio” Study
title Poly(2-hydroxyethyl methacrylate)-quercetin Conjugate as Biomaterial in Ophthalmology: An “ab initio” Study
title_full Poly(2-hydroxyethyl methacrylate)-quercetin Conjugate as Biomaterial in Ophthalmology: An “ab initio” Study
title_fullStr Poly(2-hydroxyethyl methacrylate)-quercetin Conjugate as Biomaterial in Ophthalmology: An “ab initio” Study
title_full_unstemmed Poly(2-hydroxyethyl methacrylate)-quercetin Conjugate as Biomaterial in Ophthalmology: An “ab initio” Study
title_short Poly(2-hydroxyethyl methacrylate)-quercetin Conjugate as Biomaterial in Ophthalmology: An “ab initio” Study
title_sort poly(2-hydroxyethyl methacrylate)-quercetin conjugate as biomaterial in ophthalmology: an “ab initio” study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030902/
https://www.ncbi.nlm.nih.gov/pubmed/24956059
http://dx.doi.org/10.3390/jfb2010001
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