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The Effects of Uniquely-Processed Titanium on Biological Systems: Implications for Human Health and Performance

Titanium is biocompatible and widely utilized in a variety of applications. Recently, titanium in pico-nanometer scale and soluble form (Aqua Titan) has expanded its use to applied human health and performance. The purpose of this article is to review the current evidence associated with specific ph...

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Autores principales: Rowlands, David S., Shultz, Sarah P., Ogawa, Takahiro, Aoi, Wataru, Korte, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030905/
https://www.ncbi.nlm.nih.gov/pubmed/24956353
http://dx.doi.org/10.3390/jfb5010001
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author Rowlands, David S.
Shultz, Sarah P.
Ogawa, Takahiro
Aoi, Wataru
Korte, Martin
author_facet Rowlands, David S.
Shultz, Sarah P.
Ogawa, Takahiro
Aoi, Wataru
Korte, Martin
author_sort Rowlands, David S.
collection PubMed
description Titanium is biocompatible and widely utilized in a variety of applications. Recently, titanium in pico-nanometer scale and soluble form (Aqua Titan) has expanded its use to applied human health and performance. The purpose of this article is to review the current evidence associated with specific physiological responses to Aqua Titan-treated materials. In vitro studies have shown that application of Aqua Titan can modify membrane potential and long-term potentiation in isolated hippocampal neurons, suggesting reduced pain memory as a possible mechanism for reported analgesia. Proximal contact with Aqua Titan-treated titanium increased gene expression, protein synthesis, cell growth and adhesion in normal cultured muscle and bone cells, suggesting application for Aqua Titan in clinical implant procedures and wound healing. Evidence for beneficial effects on neuromuscular control of muscle-tendon function and improvements in running economy in human athletes was seen when Aqua Titan-treated tape was applied to the human triceps surae following fatigue induced by prior strenuous exercise. Finally, behavioral responses and effects on the autonomic nervous system to environmental exposure suggest Aqua Titan may promote a mild relaxant, or stress-suppressive response. Together, data suggest exposure to Aqua Titan-treated materials modulates aspects of growth and function in neuronal and other musculoskeletal cells with possible benefits to musculotendinous recovery from exercise and to the systemic response to stress.
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spelling pubmed-40309052014-06-12 The Effects of Uniquely-Processed Titanium on Biological Systems: Implications for Human Health and Performance Rowlands, David S. Shultz, Sarah P. Ogawa, Takahiro Aoi, Wataru Korte, Martin J Funct Biomater Review Titanium is biocompatible and widely utilized in a variety of applications. Recently, titanium in pico-nanometer scale and soluble form (Aqua Titan) has expanded its use to applied human health and performance. The purpose of this article is to review the current evidence associated with specific physiological responses to Aqua Titan-treated materials. In vitro studies have shown that application of Aqua Titan can modify membrane potential and long-term potentiation in isolated hippocampal neurons, suggesting reduced pain memory as a possible mechanism for reported analgesia. Proximal contact with Aqua Titan-treated titanium increased gene expression, protein synthesis, cell growth and adhesion in normal cultured muscle and bone cells, suggesting application for Aqua Titan in clinical implant procedures and wound healing. Evidence for beneficial effects on neuromuscular control of muscle-tendon function and improvements in running economy in human athletes was seen when Aqua Titan-treated tape was applied to the human triceps surae following fatigue induced by prior strenuous exercise. Finally, behavioral responses and effects on the autonomic nervous system to environmental exposure suggest Aqua Titan may promote a mild relaxant, or stress-suppressive response. Together, data suggest exposure to Aqua Titan-treated materials modulates aspects of growth and function in neuronal and other musculoskeletal cells with possible benefits to musculotendinous recovery from exercise and to the systemic response to stress. MDPI 2014-01-03 /pmc/articles/PMC4030905/ /pubmed/24956353 http://dx.doi.org/10.3390/jfb5010001 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Rowlands, David S.
Shultz, Sarah P.
Ogawa, Takahiro
Aoi, Wataru
Korte, Martin
The Effects of Uniquely-Processed Titanium on Biological Systems: Implications for Human Health and Performance
title The Effects of Uniquely-Processed Titanium on Biological Systems: Implications for Human Health and Performance
title_full The Effects of Uniquely-Processed Titanium on Biological Systems: Implications for Human Health and Performance
title_fullStr The Effects of Uniquely-Processed Titanium on Biological Systems: Implications for Human Health and Performance
title_full_unstemmed The Effects of Uniquely-Processed Titanium on Biological Systems: Implications for Human Health and Performance
title_short The Effects of Uniquely-Processed Titanium on Biological Systems: Implications for Human Health and Performance
title_sort effects of uniquely-processed titanium on biological systems: implications for human health and performance
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030905/
https://www.ncbi.nlm.nih.gov/pubmed/24956353
http://dx.doi.org/10.3390/jfb5010001
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