Design and in Vitro Biocompatibility of a Novel Ocular Drug Delivery Device

The capsule drug ring (CDR) is a reservoir and delivery agent, which is designed to be placed within the capsular bag during cataract surgery. Prototypes were manufactured by hot melt extrusion of Bionate II(®), a polycarbonate urethane. The devices have been optimized using Avastin(®) as the drug o...

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Autores principales: Gooch, Nathan, Burr, Randon Michael, Holt, Dolly J., Gale, Bruce, Ambati, Balamurali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030910/
https://www.ncbi.nlm.nih.gov/pubmed/24955828
http://dx.doi.org/10.3390/jfb4010014
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author Gooch, Nathan
Burr, Randon Michael
Holt, Dolly J.
Gale, Bruce
Ambati, Balamurali
author_facet Gooch, Nathan
Burr, Randon Michael
Holt, Dolly J.
Gale, Bruce
Ambati, Balamurali
author_sort Gooch, Nathan
collection PubMed
description The capsule drug ring (CDR) is a reservoir and delivery agent, which is designed to be placed within the capsular bag during cataract surgery. Prototypes were manufactured by hot melt extrusion of Bionate II(®), a polycarbonate urethane. The devices have been optimized using Avastin(®) as the drug of interest. In vitro biocompatibility was assessed with human lens epithelial cell (B-3), mouse macrophage (J774A.1) and mouse fibroblast (L-929) cell lines. Cell migration and proliferation were assessed after in vitro culture. Pro-inflammatory cytokines (i.e., MIP-1β, MIP-1α, MCP-1, IL-1β, TNF and TGF-β1) were quantified using cytometric bead array (CBA). Preliminary in vivo biocompatibility and pharmacokinetics testing has been performed in rabbits.
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spelling pubmed-40309102014-06-12 Design and in Vitro Biocompatibility of a Novel Ocular Drug Delivery Device Gooch, Nathan Burr, Randon Michael Holt, Dolly J. Gale, Bruce Ambati, Balamurali J Funct Biomater Article The capsule drug ring (CDR) is a reservoir and delivery agent, which is designed to be placed within the capsular bag during cataract surgery. Prototypes were manufactured by hot melt extrusion of Bionate II(®), a polycarbonate urethane. The devices have been optimized using Avastin(®) as the drug of interest. In vitro biocompatibility was assessed with human lens epithelial cell (B-3), mouse macrophage (J774A.1) and mouse fibroblast (L-929) cell lines. Cell migration and proliferation were assessed after in vitro culture. Pro-inflammatory cytokines (i.e., MIP-1β, MIP-1α, MCP-1, IL-1β, TNF and TGF-β1) were quantified using cytometric bead array (CBA). Preliminary in vivo biocompatibility and pharmacokinetics testing has been performed in rabbits. MDPI 2013-01-18 /pmc/articles/PMC4030910/ /pubmed/24955828 http://dx.doi.org/10.3390/jfb4010014 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Gooch, Nathan
Burr, Randon Michael
Holt, Dolly J.
Gale, Bruce
Ambati, Balamurali
Design and in Vitro Biocompatibility of a Novel Ocular Drug Delivery Device
title Design and in Vitro Biocompatibility of a Novel Ocular Drug Delivery Device
title_full Design and in Vitro Biocompatibility of a Novel Ocular Drug Delivery Device
title_fullStr Design and in Vitro Biocompatibility of a Novel Ocular Drug Delivery Device
title_full_unstemmed Design and in Vitro Biocompatibility of a Novel Ocular Drug Delivery Device
title_short Design and in Vitro Biocompatibility of a Novel Ocular Drug Delivery Device
title_sort design and in vitro biocompatibility of a novel ocular drug delivery device
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030910/
https://www.ncbi.nlm.nih.gov/pubmed/24955828
http://dx.doi.org/10.3390/jfb4010014
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AT galebruce designandinvitrobiocompatibilityofanoveloculardrugdeliverydevice
AT ambatibalamurali designandinvitrobiocompatibilityofanoveloculardrugdeliverydevice

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