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Strategic Design and Fabrication of Engineered Scaffolds for Articular Cartilage Repair
Damage to articular cartilage can eventually lead to osteoarthritis (OA), a debilitating, degenerative joint disease that affects millions of people around the world. The limited natural healing ability of cartilage and the limitations of currently available therapies make treatment of cartilage def...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030923/ https://www.ncbi.nlm.nih.gov/pubmed/24955748 http://dx.doi.org/10.3390/jfb3040799 |
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author | Izadifar, Zohreh Chen, Xiongbiao Kulyk, William |
author_facet | Izadifar, Zohreh Chen, Xiongbiao Kulyk, William |
author_sort | Izadifar, Zohreh |
collection | PubMed |
description | Damage to articular cartilage can eventually lead to osteoarthritis (OA), a debilitating, degenerative joint disease that affects millions of people around the world. The limited natural healing ability of cartilage and the limitations of currently available therapies make treatment of cartilage defects a challenging clinical issue. Hopes have been raised for the repair of articular cartilage with the help of supportive structures, called scaffolds, created through tissue engineering (TE). Over the past two decades, different designs and fabrication techniques have been investigated for developing TE scaffolds suitable for the construction of transplantable artificial cartilage tissue substitutes. Advances in fabrication technologies now enable the strategic design of scaffolds with complex, biomimetic structures and properties. In particular, scaffolds with hybrid and/or biomimetic zonal designs have recently been developed for cartilage tissue engineering applications. This paper reviews critical aspects of the design of engineered scaffolds for articular cartilage repair as well as the available advanced fabrication techniques. In addition, recent studies on the design of hybrid and zonal scaffolds for use in cartilage tissue repair are highlighted. |
format | Online Article Text |
id | pubmed-4030923 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-40309232014-06-12 Strategic Design and Fabrication of Engineered Scaffolds for Articular Cartilage Repair Izadifar, Zohreh Chen, Xiongbiao Kulyk, William J Funct Biomater Review Damage to articular cartilage can eventually lead to osteoarthritis (OA), a debilitating, degenerative joint disease that affects millions of people around the world. The limited natural healing ability of cartilage and the limitations of currently available therapies make treatment of cartilage defects a challenging clinical issue. Hopes have been raised for the repair of articular cartilage with the help of supportive structures, called scaffolds, created through tissue engineering (TE). Over the past two decades, different designs and fabrication techniques have been investigated for developing TE scaffolds suitable for the construction of transplantable artificial cartilage tissue substitutes. Advances in fabrication technologies now enable the strategic design of scaffolds with complex, biomimetic structures and properties. In particular, scaffolds with hybrid and/or biomimetic zonal designs have recently been developed for cartilage tissue engineering applications. This paper reviews critical aspects of the design of engineered scaffolds for articular cartilage repair as well as the available advanced fabrication techniques. In addition, recent studies on the design of hybrid and zonal scaffolds for use in cartilage tissue repair are highlighted. MDPI 2012-11-14 /pmc/articles/PMC4030923/ /pubmed/24955748 http://dx.doi.org/10.3390/jfb3040799 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Izadifar, Zohreh Chen, Xiongbiao Kulyk, William Strategic Design and Fabrication of Engineered Scaffolds for Articular Cartilage Repair |
title | Strategic Design and Fabrication of Engineered Scaffolds for Articular Cartilage Repair |
title_full | Strategic Design and Fabrication of Engineered Scaffolds for Articular Cartilage Repair |
title_fullStr | Strategic Design and Fabrication of Engineered Scaffolds for Articular Cartilage Repair |
title_full_unstemmed | Strategic Design and Fabrication of Engineered Scaffolds for Articular Cartilage Repair |
title_short | Strategic Design and Fabrication of Engineered Scaffolds for Articular Cartilage Repair |
title_sort | strategic design and fabrication of engineered scaffolds for articular cartilage repair |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030923/ https://www.ncbi.nlm.nih.gov/pubmed/24955748 http://dx.doi.org/10.3390/jfb3040799 |
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