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Computational Study of pH-sensitive Hydrogel-based Microfluidic Flow Controllers
This computational study investigates the sensing and actuating behavior of a pH-sensitive hydrogel-based microfluidic flow controller. This hydrogel-based flow controller has inherent advantage in its unique stimuli-sensitive properties, removing the need for an external power supply. The predicted...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030935/ https://www.ncbi.nlm.nih.gov/pubmed/24956303 http://dx.doi.org/10.3390/jfb2030195 |
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author | Kurnia, Jundika C. Birgersson, Erik Mujumdar, Arun S. |
author_facet | Kurnia, Jundika C. Birgersson, Erik Mujumdar, Arun S. |
author_sort | Kurnia, Jundika C. |
collection | PubMed |
description | This computational study investigates the sensing and actuating behavior of a pH-sensitive hydrogel-based microfluidic flow controller. This hydrogel-based flow controller has inherent advantage in its unique stimuli-sensitive properties, removing the need for an external power supply. The predicted swelling behavior the hydrogel is validated with steady-state and transient experiments. We then demonstrate how the model is implemented to study the sensing and actuating behavior of hydrogels for different microfluidic flow channel/hydrogel configurations: e.g., for flow in a T-junction with single and multiple hydrogels. In short, the results suggest that the response of the hydrogel-based flow controller is slow. Therefore, two strategies to improve the response rate of the hydrogels are proposed and demonstrated. Finally, we highlight that the model can be extended to include other stimuli-responsive hydrogels such as thermo-, electric-, and glucose-sensitive hydrogels. |
format | Online Article Text |
id | pubmed-4030935 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-40309352014-06-12 Computational Study of pH-sensitive Hydrogel-based Microfluidic Flow Controllers Kurnia, Jundika C. Birgersson, Erik Mujumdar, Arun S. J Funct Biomater Article This computational study investigates the sensing and actuating behavior of a pH-sensitive hydrogel-based microfluidic flow controller. This hydrogel-based flow controller has inherent advantage in its unique stimuli-sensitive properties, removing the need for an external power supply. The predicted swelling behavior the hydrogel is validated with steady-state and transient experiments. We then demonstrate how the model is implemented to study the sensing and actuating behavior of hydrogels for different microfluidic flow channel/hydrogel configurations: e.g., for flow in a T-junction with single and multiple hydrogels. In short, the results suggest that the response of the hydrogel-based flow controller is slow. Therefore, two strategies to improve the response rate of the hydrogels are proposed and demonstrated. Finally, we highlight that the model can be extended to include other stimuli-responsive hydrogels such as thermo-, electric-, and glucose-sensitive hydrogels. MDPI 2011-08-25 /pmc/articles/PMC4030935/ /pubmed/24956303 http://dx.doi.org/10.3390/jfb2030195 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Kurnia, Jundika C. Birgersson, Erik Mujumdar, Arun S. Computational Study of pH-sensitive Hydrogel-based Microfluidic Flow Controllers |
title | Computational Study of pH-sensitive Hydrogel-based Microfluidic Flow Controllers |
title_full | Computational Study of pH-sensitive Hydrogel-based Microfluidic Flow Controllers |
title_fullStr | Computational Study of pH-sensitive Hydrogel-based Microfluidic Flow Controllers |
title_full_unstemmed | Computational Study of pH-sensitive Hydrogel-based Microfluidic Flow Controllers |
title_short | Computational Study of pH-sensitive Hydrogel-based Microfluidic Flow Controllers |
title_sort | computational study of ph-sensitive hydrogel-based microfluidic flow controllers |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030935/ https://www.ncbi.nlm.nih.gov/pubmed/24956303 http://dx.doi.org/10.3390/jfb2030195 |
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