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The Impact of Sphingosine Kinase-1 in Head and Neck Cancer
Head and neck squamous cell carcinoma (HNSCC) has a high reoccurrence rate and an extremely low survival rate. There is limited availability of effective therapies to reduce the rate of recurrence, resulting in high morbidity and mortality of advanced cases. Late presentation, delay in detection of...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030949/ https://www.ncbi.nlm.nih.gov/pubmed/24970177 http://dx.doi.org/10.3390/biom3030481 |
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author | Tamashiro, Paulette M. Furuya, Hideki Shimizu, Yoshiko Iino, Kayoko Kawamori, Toshihiko |
author_facet | Tamashiro, Paulette M. Furuya, Hideki Shimizu, Yoshiko Iino, Kayoko Kawamori, Toshihiko |
author_sort | Tamashiro, Paulette M. |
collection | PubMed |
description | Head and neck squamous cell carcinoma (HNSCC) has a high reoccurrence rate and an extremely low survival rate. There is limited availability of effective therapies to reduce the rate of recurrence, resulting in high morbidity and mortality of advanced cases. Late presentation, delay in detection of lesions, and a high rate of metastasis make HNSCC a devastating disease. This review offers insight into the role of sphingosine kinase-1 (SphK1), a key enzyme in sphingolipid metabolism, in HNSCC. Sphingolipids not only play a structural role in cellular membranes, but also modulate cell signal transduction pathways to influence biological outcomes such as senescence, differentiation, apoptosis, migration, proliferation, and angiogenesis. SphK1 is a critical regulator of the delicate balance between proliferation and apoptosis. The highest expression of SphK1 is found in the advanced stage of disease, and there is a positive correlation between SphK1 expression and recurrent tumors. On the other hand, silencing SphK1 reduces HNSCC tumor growth and sensitizes tumors to radiation-induced death. Thus, SphK1 plays an important and influential role in determining HNSCC proliferation and metastasis. We discuss roles of SphK1 and other sphingolipids in HNSCC development and therapeutic strategies against HNSCC. |
format | Online Article Text |
id | pubmed-4030949 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-40309492014-06-24 The Impact of Sphingosine Kinase-1 in Head and Neck Cancer Tamashiro, Paulette M. Furuya, Hideki Shimizu, Yoshiko Iino, Kayoko Kawamori, Toshihiko Biomolecules Review Head and neck squamous cell carcinoma (HNSCC) has a high reoccurrence rate and an extremely low survival rate. There is limited availability of effective therapies to reduce the rate of recurrence, resulting in high morbidity and mortality of advanced cases. Late presentation, delay in detection of lesions, and a high rate of metastasis make HNSCC a devastating disease. This review offers insight into the role of sphingosine kinase-1 (SphK1), a key enzyme in sphingolipid metabolism, in HNSCC. Sphingolipids not only play a structural role in cellular membranes, but also modulate cell signal transduction pathways to influence biological outcomes such as senescence, differentiation, apoptosis, migration, proliferation, and angiogenesis. SphK1 is a critical regulator of the delicate balance between proliferation and apoptosis. The highest expression of SphK1 is found in the advanced stage of disease, and there is a positive correlation between SphK1 expression and recurrent tumors. On the other hand, silencing SphK1 reduces HNSCC tumor growth and sensitizes tumors to radiation-induced death. Thus, SphK1 plays an important and influential role in determining HNSCC proliferation and metastasis. We discuss roles of SphK1 and other sphingolipids in HNSCC development and therapeutic strategies against HNSCC. MDPI 2013-08-12 /pmc/articles/PMC4030949/ /pubmed/24970177 http://dx.doi.org/10.3390/biom3030481 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Tamashiro, Paulette M. Furuya, Hideki Shimizu, Yoshiko Iino, Kayoko Kawamori, Toshihiko The Impact of Sphingosine Kinase-1 in Head and Neck Cancer |
title | The Impact of Sphingosine Kinase-1 in Head and Neck Cancer |
title_full | The Impact of Sphingosine Kinase-1 in Head and Neck Cancer |
title_fullStr | The Impact of Sphingosine Kinase-1 in Head and Neck Cancer |
title_full_unstemmed | The Impact of Sphingosine Kinase-1 in Head and Neck Cancer |
title_short | The Impact of Sphingosine Kinase-1 in Head and Neck Cancer |
title_sort | impact of sphingosine kinase-1 in head and neck cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030949/ https://www.ncbi.nlm.nih.gov/pubmed/24970177 http://dx.doi.org/10.3390/biom3030481 |
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