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The Impact of Sphingosine Kinase-1 in Head and Neck Cancer

Head and neck squamous cell carcinoma (HNSCC) has a high reoccurrence rate and an extremely low survival rate. There is limited availability of effective therapies to reduce the rate of recurrence, resulting in high morbidity and mortality of advanced cases. Late presentation, delay in detection of...

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Autores principales: Tamashiro, Paulette M., Furuya, Hideki, Shimizu, Yoshiko, Iino, Kayoko, Kawamori, Toshihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030949/
https://www.ncbi.nlm.nih.gov/pubmed/24970177
http://dx.doi.org/10.3390/biom3030481
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author Tamashiro, Paulette M.
Furuya, Hideki
Shimizu, Yoshiko
Iino, Kayoko
Kawamori, Toshihiko
author_facet Tamashiro, Paulette M.
Furuya, Hideki
Shimizu, Yoshiko
Iino, Kayoko
Kawamori, Toshihiko
author_sort Tamashiro, Paulette M.
collection PubMed
description Head and neck squamous cell carcinoma (HNSCC) has a high reoccurrence rate and an extremely low survival rate. There is limited availability of effective therapies to reduce the rate of recurrence, resulting in high morbidity and mortality of advanced cases. Late presentation, delay in detection of lesions, and a high rate of metastasis make HNSCC a devastating disease. This review offers insight into the role of sphingosine kinase-1 (SphK1), a key enzyme in sphingolipid metabolism, in HNSCC. Sphingolipids not only play a structural role in cellular membranes, but also modulate cell signal transduction pathways to influence biological outcomes such as senescence, differentiation, apoptosis, migration, proliferation, and angiogenesis. SphK1 is a critical regulator of the delicate balance between proliferation and apoptosis. The highest expression of SphK1 is found in the advanced stage of disease, and there is a positive correlation between SphK1 expression and recurrent tumors. On the other hand, silencing SphK1 reduces HNSCC tumor growth and sensitizes tumors to radiation-induced death. Thus, SphK1 plays an important and influential role in determining HNSCC proliferation and metastasis. We discuss roles of SphK1 and other sphingolipids in HNSCC development and therapeutic strategies against HNSCC.
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spelling pubmed-40309492014-06-24 The Impact of Sphingosine Kinase-1 in Head and Neck Cancer Tamashiro, Paulette M. Furuya, Hideki Shimizu, Yoshiko Iino, Kayoko Kawamori, Toshihiko Biomolecules Review Head and neck squamous cell carcinoma (HNSCC) has a high reoccurrence rate and an extremely low survival rate. There is limited availability of effective therapies to reduce the rate of recurrence, resulting in high morbidity and mortality of advanced cases. Late presentation, delay in detection of lesions, and a high rate of metastasis make HNSCC a devastating disease. This review offers insight into the role of sphingosine kinase-1 (SphK1), a key enzyme in sphingolipid metabolism, in HNSCC. Sphingolipids not only play a structural role in cellular membranes, but also modulate cell signal transduction pathways to influence biological outcomes such as senescence, differentiation, apoptosis, migration, proliferation, and angiogenesis. SphK1 is a critical regulator of the delicate balance between proliferation and apoptosis. The highest expression of SphK1 is found in the advanced stage of disease, and there is a positive correlation between SphK1 expression and recurrent tumors. On the other hand, silencing SphK1 reduces HNSCC tumor growth and sensitizes tumors to radiation-induced death. Thus, SphK1 plays an important and influential role in determining HNSCC proliferation and metastasis. We discuss roles of SphK1 and other sphingolipids in HNSCC development and therapeutic strategies against HNSCC. MDPI 2013-08-12 /pmc/articles/PMC4030949/ /pubmed/24970177 http://dx.doi.org/10.3390/biom3030481 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Tamashiro, Paulette M.
Furuya, Hideki
Shimizu, Yoshiko
Iino, Kayoko
Kawamori, Toshihiko
The Impact of Sphingosine Kinase-1 in Head and Neck Cancer
title The Impact of Sphingosine Kinase-1 in Head and Neck Cancer
title_full The Impact of Sphingosine Kinase-1 in Head and Neck Cancer
title_fullStr The Impact of Sphingosine Kinase-1 in Head and Neck Cancer
title_full_unstemmed The Impact of Sphingosine Kinase-1 in Head and Neck Cancer
title_short The Impact of Sphingosine Kinase-1 in Head and Neck Cancer
title_sort impact of sphingosine kinase-1 in head and neck cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030949/
https://www.ncbi.nlm.nih.gov/pubmed/24970177
http://dx.doi.org/10.3390/biom3030481
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