pH-Sensitive Hydrogel for Micro-Fluidic Valve
The deformation behavior of a pH-sensitive hydrogel micro-fluidic valve system is investigated using inhomogeneous gel deformation theory, in which the fluid-structure interaction (FSI) of the gel solid and fluid flow in the pipe is considered. We use a finite element method with a well adopted hydr...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031000/ https://www.ncbi.nlm.nih.gov/pubmed/24955627 http://dx.doi.org/10.3390/jfb3030464 |
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author | Zhang, Yan Liu, Zishun Swaddiwudhipong, Somsak Miao, Haiyan Ding, Zhiwei Yang, Zhengzhi |
author_facet | Zhang, Yan Liu, Zishun Swaddiwudhipong, Somsak Miao, Haiyan Ding, Zhiwei Yang, Zhengzhi |
author_sort | Zhang, Yan |
collection | PubMed |
description | The deformation behavior of a pH-sensitive hydrogel micro-fluidic valve system is investigated using inhomogeneous gel deformation theory, in which the fluid-structure interaction (FSI) of the gel solid and fluid flow in the pipe is considered. We use a finite element method with a well adopted hydrogel constitutive equation, which is coded in commercial software, ABAQUS, to simulate the hydrogel valve swelling deformation, while FLUENT is adopted to model the fluid flow in the pipe of the hydrogel valve system. The study demonstrates that FSI significantly affects the gel swelling deformed shapes, fluid flow pressure and velocity patterns. FSI has to be considered in the study on fluid flow regulated by hydrogel microfluidic valve. The study provides a more accurate and adoptable model for future design of new pH-sensitive hydrogel valves, and also gives a useful guideline for further studies on hydrogel fluidic applications. |
format | Online Article Text |
id | pubmed-4031000 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-40310002014-06-12 pH-Sensitive Hydrogel for Micro-Fluidic Valve Zhang, Yan Liu, Zishun Swaddiwudhipong, Somsak Miao, Haiyan Ding, Zhiwei Yang, Zhengzhi J Funct Biomater Article The deformation behavior of a pH-sensitive hydrogel micro-fluidic valve system is investigated using inhomogeneous gel deformation theory, in which the fluid-structure interaction (FSI) of the gel solid and fluid flow in the pipe is considered. We use a finite element method with a well adopted hydrogel constitutive equation, which is coded in commercial software, ABAQUS, to simulate the hydrogel valve swelling deformation, while FLUENT is adopted to model the fluid flow in the pipe of the hydrogel valve system. The study demonstrates that FSI significantly affects the gel swelling deformed shapes, fluid flow pressure and velocity patterns. FSI has to be considered in the study on fluid flow regulated by hydrogel microfluidic valve. The study provides a more accurate and adoptable model for future design of new pH-sensitive hydrogel valves, and also gives a useful guideline for further studies on hydrogel fluidic applications. MDPI 2012-07-10 /pmc/articles/PMC4031000/ /pubmed/24955627 http://dx.doi.org/10.3390/jfb3030464 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Zhang, Yan Liu, Zishun Swaddiwudhipong, Somsak Miao, Haiyan Ding, Zhiwei Yang, Zhengzhi pH-Sensitive Hydrogel for Micro-Fluidic Valve |
title | pH-Sensitive Hydrogel for Micro-Fluidic Valve |
title_full | pH-Sensitive Hydrogel for Micro-Fluidic Valve |
title_fullStr | pH-Sensitive Hydrogel for Micro-Fluidic Valve |
title_full_unstemmed | pH-Sensitive Hydrogel for Micro-Fluidic Valve |
title_short | pH-Sensitive Hydrogel for Micro-Fluidic Valve |
title_sort | ph-sensitive hydrogel for micro-fluidic valve |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031000/ https://www.ncbi.nlm.nih.gov/pubmed/24955627 http://dx.doi.org/10.3390/jfb3030464 |
work_keys_str_mv | AT zhangyan phsensitivehydrogelformicrofluidicvalve AT liuzishun phsensitivehydrogelformicrofluidicvalve AT swaddiwudhipongsomsak phsensitivehydrogelformicrofluidicvalve AT miaohaiyan phsensitivehydrogelformicrofluidicvalve AT dingzhiwei phsensitivehydrogelformicrofluidicvalve AT yangzhengzhi phsensitivehydrogelformicrofluidicvalve |