pH-Sensitive Hydrogel for Micro-Fluidic Valve

The deformation behavior of a pH-sensitive hydrogel micro-fluidic valve system is investigated using inhomogeneous gel deformation theory, in which the fluid-structure interaction (FSI) of the gel solid and fluid flow in the pipe is considered. We use a finite element method with a well adopted hydr...

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Detalles Bibliográficos
Autores principales: Zhang, Yan, Liu, Zishun, Swaddiwudhipong, Somsak, Miao, Haiyan, Ding, Zhiwei, Yang, Zhengzhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031000/
https://www.ncbi.nlm.nih.gov/pubmed/24955627
http://dx.doi.org/10.3390/jfb3030464
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author Zhang, Yan
Liu, Zishun
Swaddiwudhipong, Somsak
Miao, Haiyan
Ding, Zhiwei
Yang, Zhengzhi
author_facet Zhang, Yan
Liu, Zishun
Swaddiwudhipong, Somsak
Miao, Haiyan
Ding, Zhiwei
Yang, Zhengzhi
author_sort Zhang, Yan
collection PubMed
description The deformation behavior of a pH-sensitive hydrogel micro-fluidic valve system is investigated using inhomogeneous gel deformation theory, in which the fluid-structure interaction (FSI) of the gel solid and fluid flow in the pipe is considered. We use a finite element method with a well adopted hydrogel constitutive equation, which is coded in commercial software, ABAQUS, to simulate the hydrogel valve swelling deformation, while FLUENT is adopted to model the fluid flow in the pipe of the hydrogel valve system. The study demonstrates that FSI significantly affects the gel swelling deformed shapes, fluid flow pressure and velocity patterns. FSI has to be considered in the study on fluid flow regulated by hydrogel microfluidic valve. The study provides a more accurate and adoptable model for future design of new pH-sensitive hydrogel valves, and also gives a useful guideline for further studies on hydrogel fluidic applications.
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spelling pubmed-40310002014-06-12 pH-Sensitive Hydrogel for Micro-Fluidic Valve Zhang, Yan Liu, Zishun Swaddiwudhipong, Somsak Miao, Haiyan Ding, Zhiwei Yang, Zhengzhi J Funct Biomater Article The deformation behavior of a pH-sensitive hydrogel micro-fluidic valve system is investigated using inhomogeneous gel deformation theory, in which the fluid-structure interaction (FSI) of the gel solid and fluid flow in the pipe is considered. We use a finite element method with a well adopted hydrogel constitutive equation, which is coded in commercial software, ABAQUS, to simulate the hydrogel valve swelling deformation, while FLUENT is adopted to model the fluid flow in the pipe of the hydrogel valve system. The study demonstrates that FSI significantly affects the gel swelling deformed shapes, fluid flow pressure and velocity patterns. FSI has to be considered in the study on fluid flow regulated by hydrogel microfluidic valve. The study provides a more accurate and adoptable model for future design of new pH-sensitive hydrogel valves, and also gives a useful guideline for further studies on hydrogel fluidic applications. MDPI 2012-07-10 /pmc/articles/PMC4031000/ /pubmed/24955627 http://dx.doi.org/10.3390/jfb3030464 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Zhang, Yan
Liu, Zishun
Swaddiwudhipong, Somsak
Miao, Haiyan
Ding, Zhiwei
Yang, Zhengzhi
pH-Sensitive Hydrogel for Micro-Fluidic Valve
title pH-Sensitive Hydrogel for Micro-Fluidic Valve
title_full pH-Sensitive Hydrogel for Micro-Fluidic Valve
title_fullStr pH-Sensitive Hydrogel for Micro-Fluidic Valve
title_full_unstemmed pH-Sensitive Hydrogel for Micro-Fluidic Valve
title_short pH-Sensitive Hydrogel for Micro-Fluidic Valve
title_sort ph-sensitive hydrogel for micro-fluidic valve
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031000/
https://www.ncbi.nlm.nih.gov/pubmed/24955627
http://dx.doi.org/10.3390/jfb3030464
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AT swaddiwudhipongsomsak phsensitivehydrogelformicrofluidicvalve
AT miaohaiyan phsensitivehydrogelformicrofluidicvalve
AT dingzhiwei phsensitivehydrogelformicrofluidicvalve
AT yangzhengzhi phsensitivehydrogelformicrofluidicvalve