Six Homeoproteins and a linc-RNA at the Fast MYH Locus Lock Fast Myofiber Terminal Phenotype

Thousands of long intergenic non-coding RNAs (lincRNAs) are encoded by the mammalian genome. However, the function of most of these lincRNAs has not been identified in vivo. Here, we demonstrate a role for a novel lincRNA, linc-MYH, in adult fast-type myofiber specialization. Fast myosin heavy chain...

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Detalles Bibliográficos
Autores principales: Sakakibara, Iori, Santolini, Marc, Ferry, Arnaud, Hakim, Vincent, Maire, Pascal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031048/
https://www.ncbi.nlm.nih.gov/pubmed/24852826
http://dx.doi.org/10.1371/journal.pgen.1004386
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author Sakakibara, Iori
Santolini, Marc
Ferry, Arnaud
Hakim, Vincent
Maire, Pascal
author_facet Sakakibara, Iori
Santolini, Marc
Ferry, Arnaud
Hakim, Vincent
Maire, Pascal
author_sort Sakakibara, Iori
collection PubMed
description Thousands of long intergenic non-coding RNAs (lincRNAs) are encoded by the mammalian genome. However, the function of most of these lincRNAs has not been identified in vivo. Here, we demonstrate a role for a novel lincRNA, linc-MYH, in adult fast-type myofiber specialization. Fast myosin heavy chain (MYH) genes and linc-MYH share a common enhancer, located in the fast MYH gene locus and regulated by Six1 homeoproteins. linc-MYH in nuclei of fast-type myofibers prevents slow-type and enhances fast-type gene expression. Functional fast-sarcomeric unit formation is achieved by the coordinate expression of fast MYHs and linc-MYH, under the control of a common Six-bound enhancer.
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spelling pubmed-40310482014-05-28 Six Homeoproteins and a linc-RNA at the Fast MYH Locus Lock Fast Myofiber Terminal Phenotype Sakakibara, Iori Santolini, Marc Ferry, Arnaud Hakim, Vincent Maire, Pascal PLoS Genet Research Article Thousands of long intergenic non-coding RNAs (lincRNAs) are encoded by the mammalian genome. However, the function of most of these lincRNAs has not been identified in vivo. Here, we demonstrate a role for a novel lincRNA, linc-MYH, in adult fast-type myofiber specialization. Fast myosin heavy chain (MYH) genes and linc-MYH share a common enhancer, located in the fast MYH gene locus and regulated by Six1 homeoproteins. linc-MYH in nuclei of fast-type myofibers prevents slow-type and enhances fast-type gene expression. Functional fast-sarcomeric unit formation is achieved by the coordinate expression of fast MYHs and linc-MYH, under the control of a common Six-bound enhancer. Public Library of Science 2014-05-22 /pmc/articles/PMC4031048/ /pubmed/24852826 http://dx.doi.org/10.1371/journal.pgen.1004386 Text en © 2014 Sakakibara et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Sakakibara, Iori
Santolini, Marc
Ferry, Arnaud
Hakim, Vincent
Maire, Pascal
Six Homeoproteins and a linc-RNA at the Fast MYH Locus Lock Fast Myofiber Terminal Phenotype
title Six Homeoproteins and a linc-RNA at the Fast MYH Locus Lock Fast Myofiber Terminal Phenotype
title_full Six Homeoproteins and a linc-RNA at the Fast MYH Locus Lock Fast Myofiber Terminal Phenotype
title_fullStr Six Homeoproteins and a linc-RNA at the Fast MYH Locus Lock Fast Myofiber Terminal Phenotype
title_full_unstemmed Six Homeoproteins and a linc-RNA at the Fast MYH Locus Lock Fast Myofiber Terminal Phenotype
title_short Six Homeoproteins and a linc-RNA at the Fast MYH Locus Lock Fast Myofiber Terminal Phenotype
title_sort six homeoproteins and a linc-rna at the fast myh locus lock fast myofiber terminal phenotype
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031048/
https://www.ncbi.nlm.nih.gov/pubmed/24852826
http://dx.doi.org/10.1371/journal.pgen.1004386
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