Scribble Modulates the MAPK/Fra1 Pathway to Disrupt Luminal and Ductal Integrity and Suppress Tumour Formation in the Mammary Gland

Polarity coordinates cell movement, differentiation, proliferation and apoptosis to build and maintain complex epithelial tissues such as the mammary gland. Loss of polarity and the deregulation of these processes are critical events in malignant progression but precisely how and at which stage pola...

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Detalles Bibliográficos
Autores principales: Godde, Nathan J., Sheridan, Julie M., Smith, Lorey K., Pearson, Helen B., Britt, Kara L., Galea, Ryan C., Yates, Laura L., Visvader, Jane E., Humbert, Patrick O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031063/
https://www.ncbi.nlm.nih.gov/pubmed/24852022
http://dx.doi.org/10.1371/journal.pgen.1004323

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