Population Pharmacokinetic Study of Benznidazole in Pediatric Chagas Disease Suggests Efficacy despite Lower Plasma Concentrations than in Adults

INTRODUCTION: Chagas disease, caused by the parasite Trypanosoma cruzi, can lead to long term cardiac morbidity. Treatment of children with benznidazole is effective, but no pediatric pharmacokinetics data are available and clinical pharmacology information on the drug is scarce. PATIENTS AND METHOD...

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Detalles Bibliográficos
Autores principales: Altcheh, Jaime, Moscatelli, Guillermo, Mastrantonio, Guido, Moroni, Samanta, Giglio, Norberto, Marson, Maria Elena, Ballering, Griselda, Bisio, Margarita, Koren, Gideon, García-Bournissen, Facundo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031103/
https://www.ncbi.nlm.nih.gov/pubmed/24853169
http://dx.doi.org/10.1371/journal.pntd.0002907

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