Cargando…

Genome instability in blood cells of a BRCA1+ breast cancer family

BACKGROUND: BRCA1 plays an essential role in maintaining genome stability. Inherited BRCA1 germline mutation (BRCA1+) is a determined genetic predisposition leading to high risk of breast cancer. While BRCA1+ induces breast cancer by causing genome instability, most of the knowledge is known about s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xiao, Fengxia, Kim, Yeong C, Snyder, Carrie, Wen, Hongxiu, Chen, Pei Xian, Luo, Jiangtao, Becirovic, Dina, Downs, Bradley, Cowan, Kenneth H, Lynch, Henry, Wang, San Ming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031489/ https://www.ncbi.nlm.nih.gov/pubmed/24884718 http://dx.doi.org/10.1186/1471-2407-14-342

Ejemplares similares

Family-specific, novel, deleterious germline variants provide a rich resource to identify genetic predispositions for BRCAx familial breast cancer
por: Wen, Hongxiu, et al.
Publicado: (2014)

Differences of Variable Number Tandem Repeats in XRCC5 Promoter Are Associated with Increased or Decreased Risk of Breast Cancer in BRCA Gene Mutation Carriers
por: Cui, Jian, et al.
Publicado: (2016)

Prevalence and spectrum of BRCA germline variants in mainland Chinese familial breast and ovarian cancer patients
por: Kim, Yeong C., et al.
Publicado: (2016)

The Genome of Polymorphonuclear Neutrophils Maintains Normal Coding Sequences
por: Xiao, Fengxia, et al.
Publicado: (2013)

Exome-based Variant Detection in Core Promoters
por: Kim, Yeong C., et al.
Publicado: (2016)

Preferences for breast cancer prevention among women with a BRCA1 or BRCA2 mutation
por: Mansfield, Carol A., et al.
Publicado: (2020)

Contralateral mastectomy and survival after breast cancer in carriers of BRCA1 and BRCA2 mutations: retrospective analysis
por: Metcalfe, Kelly, et al.
Publicado: (2014)

Heterozygotic Brca1 mutation initiates mouse genome instability at embryonic stage
por: Wu, Xiaobing, et al.
Publicado: (2022)

Preferences for breast cancer risk reduction among BRCA1/BRCA2 mutation carriers: a discrete-choice experiment
por: Liede, Alexander, et al.
Publicado: (2017)

Oestrogen receptor status and survival in women with BRCA2-associated breast cancer
por: Metcalfe, Kelly, et al.
Publicado: (2019)

Predictors of long-term cancer-related distress among female BRCA1 and BRCA2 mutation carriers without a cancer diagnosis: an international analysis
por: Metcalfe, Kelly A., et al.
Publicado: (2020)

Haploinsufficiency for BRCA1 leads to cell-type-specific genomic instability and premature senescence
por: Sedic, Maja, et al.
Publicado: (2015)

Molecular analysis of the BRCA1 and BRCA2 genes in 32 breast and/or ovarian cancer Spanish families
por: Osorio, A, et al.
Publicado: (2000)

BRCA1 prevents R-loop-associated centromeric instability
por: Racca, Carine, et al.
Publicado: (2021)

Molecular contribution of BRCA1 and BRCA2 to genome instability in breast cancer patients: review of radiosensitivity assays
por: Sadeghi, Fatemeh, et al.
Publicado: (2020)

Genetic instability in the RAD51 and BRCA1 regions in breast cancer
por: Nowacka-Zawisza, Maria, et al.
Publicado: (2006)

Peripheral blood BRCA1 methylation profiling to predict familial ovarian cancer
por: Jung, Yuyeon, et al.
Publicado: (2021)

Mutational analysis of BRCA1 and BRCA2 genes in Peruvian families with hereditary breast and ovarian cancer
por: Buleje, Jose, et al.
Publicado: (2017)

Haplotype analysis in German families with recurrent BRCA1 and BRCA2 mutations
por: Wappenschmidt, B, et al.
Publicado: (2001)

Comments on: Peripheral blood BRCA1 methylation profiling to predict familial ovarian cancer
por: Kwon, Janice S.
Publicado: (2021)

Pan-Cancer Analysis of BRCA1 and BRCA2 Genomic Alterations and Their Association With Genomic Instability as Measured by Genome-Wide Loss of Heterozygosity
por: Sokol, Ethan S., et al.
Publicado: (2020)

Biallelic variants in BRCA1 gene cause a recognisable phenotype within chromosomal instability syndromes reframed as BRCA1 deficiency
por: Chirita-Emandi, Adela, et al.
Publicado: (2021)

BRCA1 promoter methylation in peripheral blood DNA of mutation negative familial breast cancer patients with a BRCA1 tumour phenotype
por: Snell, Cameron, et al.
Publicado: (2008)

Prevalance of BRCA1 and BRCA2 mutations in familial breast cancer patients in Lebanon
por: Jalkh, Nadine, et al.
Publicado: (2012)

Age and Geographical Distribution in Families with BRCA1/BRCA2 Mutations in the Slovak Republic
por: Ciernikova, Sona, et al.
Publicado: (2006)

BRCA1 and BRCA2 Variation in Taiwanese General Population and the Cancer Cohort
por: Chian, Jiasheng, et al.
Publicado: (2021)

Constitutional genomic instability of 9p23-24 in BRCA2 mutation carriers
por: Savelyeva, L, et al.
Publicado: (2001)

FANCD2 limits replication stress and genome instability in cells lacking BRCA2
por: Michl, Johanna, et al.
Publicado: (2016)

A Class of Environmental and Endogenous Toxins Induces BRCA2 Haploinsufficiency and Genome Instability
por: Tan, Shawn Lu Wen, et al.
Publicado: (2017)

BRCA-mutated gastric adenocarcinomas are associated with chromosomal instability and responsiveness to platinum-based chemotherapy
por: Oh, Ji Hyun, et al.
Publicado: (2023)

BRCA1 mutations in women with familial or early-onset breast cancer and BRCA2 mutations in familial cancer in Estonia
por: Tamboom, Kristiina, et al.
Publicado: (2010)

Changes in body weight and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers
por: Kotsopoulos, Joanne, et al.
Publicado: (2005)

Ethnic‐specificity, evolution origin and deleteriousness of Asian BRCA variation revealed by over 7500 BRCA variants derived from Asian population
por: Qin, Zixin, et al.
Publicado: (2022)

Characteristics of small breast and/or ovarian cancer families with germline mutations in BRCA1 and BRCA2
por: Ligtenberg, M J L, et al.
Publicado: (1999)

The pathology of familial breast cancer: The pre-BRCA1/BRCA2 era - historical perspectives
por: van de Vijver, Marc J
Publicado: (1999)

BRCA1 and BRCA2 Germline Mutations Screening in Algerian Breast/Ovarian Cancer Families
por: Cherbal, Farid, et al.
Publicado: (2010)

Germline Mutations in BRCA1 and BRCA2 in Polish Families Predisposed to Breast and Ovary Cancers
por: Grzybowska, E., et al.
Publicado: (1999)

Novel Germline Mutations of BRCA1 and BRCA2 in Korean Familial Breast Cancer Patients
por: Kim, Hee Nam, et al.
Publicado: (2019)

BRCA1 and BRCA2 in breast cancer families from Wales: moderate mutation frequency and two recurrent mutations in BRCA1.
por: Lancaster, J. M., et al.
Publicado: (1998)

Whole Exome Sequencing Suggests Much of Non-BRCA1/BRCA2 Familial Breast Cancer Is Due to Moderate and Low Penetrance Susceptibility Alleles
por: Gracia-Aznarez, Francisco Javier, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_tdubn94ntctqn510s7n8kcbv6q