Cargando…

Systems-based Discovery of Tomatidine as a Natural Small Molecule Inhibitor of Skeletal Muscle Atrophy

Skeletal muscle atrophy is a common and debilitating condition that lacks an effective therapy. To address this problem, we used a systems-based discovery strategy to search for a small molecule whose mRNA expression signature negatively correlates to mRNA expression signatures of human skeletal mus...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dyle, Michael C., Ebert, Scott M., Cook, Daniel P., Kunkel, Steven D., Fox, Daniel K., Bongers, Kale S., Bullard, Steven A., Dierdorff, Jason M., Adams, Christopher M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2014
Materias:	Metabolism
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031541/ https://www.ncbi.nlm.nih.gov/pubmed/24719321 http://dx.doi.org/10.1074/jbc.M114.556241

Ejemplares similares

Identification and Small Molecule Inhibition of an Activating Transcription Factor 4 (ATF4)-dependent Pathway to Age-related Skeletal Muscle Weakness and Atrophy
por: Ebert, Scott M., et al.
Publicado: (2015)

Ursolic Acid Increases Skeletal Muscle and Brown Fat and Decreases Diet-Induced Obesity, Glucose Intolerance and Fatty Liver Disease
por: Kunkel, Steven D., et al.
Publicado: (2012)

Gadd45a Protein Promotes Skeletal Muscle Atrophy by Forming a Complex with the Protein Kinase MEKK4
por: Bullard, Steven A., et al.
Publicado: (2016)

Use of mRNA expression signatures to discover small molecule inhibitors of skeletal muscle atrophy
por: Adams, Christopher M., et al.
Publicado: (2015)

Activating transcription factor 4 (ATF4) promotes skeletal muscle atrophy by forming a heterodimer with the transcriptional regulator C/EBPβ
por: Ebert, Scott M., et al.
Publicado: (2020)

Tomatidine Alleviates Osteoporosis by Downregulation of p53
por: Yu, Tao, et al.
Publicado: (2020)

Bactericidal Activity of the Bacterial ATP Synthase Inhibitor Tomatidine and the Combination of Tomatidine and Aminoglycoside Against Persistent and Virulent Forms of Staphylococcus aureus
por: Langlois, Jean-Philippe, et al.
Publicado: (2020)

Mechanisms of growth inhibition of Phytomonas serpens by the alkaloids tomatine and tomatidine
por: Medina, Jorge Mansur, et al.
Publicado: (2015)

Combination With Tomatidine Improves the Potency of Posaconazole Against Trypanosoma cruzi
por: Rocha-Hasler, Marianne, et al.
Publicado: (2021)

Tomatidine Improves Pulmonary Inflammation in Mice with Acute Lung Injury
por: Huang, Wen-Chung, et al.
Publicado: (2021)

Tomatidine provides mitophagy‐independent neuroprotection after ischemic injury
por: Wang, Yu‐ting, et al.
Publicado: (2021)

Impact of Perturbed Pancreatic β-Cell Cholesterol Homeostasis on Adipose Tissue and Skeletal Muscle Metabolism
por: Cochran, Blake J., et al.
Publicado: (2016)

MON-516 Skeletal Fluorosis from Fluorocarbon Inhalation
por: Seagrove-Guffey, Maighan, et al.
Publicado: (2019)

Tomatidine reduces Chikungunya virus progeny release by controlling viral protein expression
por: Troost-Kind, Berit, et al.
Publicado: (2021)

The Steroidal Alkaloid Tomatidine and Tomatidine-Rich Tomato Leaf Extract Suppress the Human Gastric Cancer-Derived 85As2 Cells In Vitro and In Vivo via Modulation of Interferon-Stimulated Genes
por: Fujimaki, Junya, et al.
Publicado: (2022)

Tomatidine targets ATF4-dependent signaling and induces ferroptosis to limit pancreatic cancer progression
por: Mukherjee, Debasmita, et al.
Publicado: (2023)

Concise Large-Scale Synthesis of Tomatidine, A Potent Antibiotic Natural Product
por: Normandin, Chad, et al.
Publicado: (2021)

Tomatidine, a natural steroidal alkaloid shows antiviral activity towards chikungunya virus in vitro
por: Troost, Berit, et al.
Publicado: (2020)

GDF15 Mediates the Effect of Skeletal Muscle Contraction on Glucose-Stimulated Insulin Secretion
por: Zhang, Hui, et al.
Publicado: (2023)

Bactericidal Effect of Tomatidine-Tobramycin Combination against Methicillin-Resistant Staphylococcus aureus and Pseudomonas aeruginosa Is Enhanced by Interspecific Small-Molecule Interactions
por: Boulanger, Simon, et al.
Publicado: (2015)

Tomatidine suppresses inflammation in primary articular chondrocytes and attenuates cartilage degradation in osteoarthritic rats
por: Chu, Xiangyu, et al.
Publicado: (2020)

Tomatidine inhibits porcine epidemic diarrhea virus replication by targeting 3CL protease
por: Wang, Pengcheng, et al.
Publicado: (2020)

Glutamine Regulates Skeletal Muscle Immunometabolism in Type 2 Diabetes
por: Dollet, Lucile, et al.
Publicado: (2022)

Kinetics of Contraction-Induced GLUT4 Translocation in Skeletal Muscle Fibers From Living Mice
por: Lauritzen, Hans P.M.M., et al.
Publicado: (2010)

Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1: A Link Between Insulin and Lipid Metabolism
por: DeAngelis, Anthony M., et al.
Publicado: (2008)

Metabolic Remodeling of Human Skeletal Myocytes by Cocultured Adipocytes Depends on the Lipolytic State of the System
por: Kovalik, Jean-Paul, et al.
Publicado: (2011)

Deletion of Skeletal Muscle SOCS3 Prevents Insulin Resistance in Obesity
por: Jorgensen, Sebastian Beck, et al.
Publicado: (2013)

Compartmentalized Acyl-CoA Metabolism in Skeletal Muscle Regulates Systemic Glucose Homeostasis
por: Li, Lei O., et al.
Publicado: (2015)

Doc2b Is a Key Effector of Insulin Secretion and Skeletal Muscle Insulin Sensitivity
por: Ramalingam, Latha, et al.
Publicado: (2012)

Total Phenolic, Flavonoid, Tomatine, and Tomatidine Contents and Antioxidant and Antimicrobial Activities of Extracts of Tomato Plant
por: Silva-Beltrán, Norma Patricia, et al.
Publicado: (2015)

Correction for: Tomatidine suppresses inflammation in primary articular chondrocytes and attenuates cartilage degradation in osteoarthritic rats
por: Chu, Xiangyu, et al.
Publicado: (2022)

Tomatidine-stimulated maturation of human embryonic stem cell-derived cardiomyocytes for modeling mitochondrial dysfunction
por: Kim, Ye Seul, et al.
Publicado: (2022)

Adiponectin Upregulates Ferritin Heavy Chain in Skeletal Muscle Cells
por: Ikegami, Yuichi, et al.
Publicado: (2009)

Role of PKCδ in Insulin Sensitivity and Skeletal Muscle Metabolism
por: Li, Mengyao, et al.
Publicado: (2015)

HSP72 Is a Mitochondrial Stress Sensor Critical for Parkin Action, Oxidative Metabolism, and Insulin Sensitivity in Skeletal Muscle
por: Drew, Brian G., et al.
Publicado: (2014)

Perilipin 2 Improves Insulin Sensitivity in Skeletal Muscle Despite Elevated Intramuscular Lipid Levels
por: Bosma, Madeleen, et al.
Publicado: (2012)

Activating HSP72 in Rodent Skeletal Muscle Increases Mitochondrial Number and Oxidative Capacity and Decreases Insulin Resistance
por: Henstridge, Darren C., et al.
Publicado: (2014)

Perilipin 5–Driven Lipid Droplet Accumulation in Skeletal Muscle Stimulates the Expression of Fibroblast Growth Factor 21
por: Harris, Lydia-Ann L.S., et al.
Publicado: (2015)

Endothelin-1 Reduces Glucose Uptake in Human Skeletal Muscle In Vivo and In Vitro
por: Shemyakin, Alexey, et al.
Publicado: (2011)

Altered Response of Skeletal Muscle to IL-6 in Type 2 Diabetic Patients
por: Jiang, Lake Q., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_vh66mdu8g0iuas66l2lf1d0iqe