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Systems-based Discovery of Tomatidine as a Natural Small Molecule Inhibitor of Skeletal Muscle Atrophy

Skeletal muscle atrophy is a common and debilitating condition that lacks an effective therapy. To address this problem, we used a systems-based discovery strategy to search for a small molecule whose mRNA expression signature negatively correlates to mRNA expression signatures of human skeletal mus...

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Detalles Bibliográficos
Autores principales:	Dyle, Michael C., Ebert, Scott M., Cook, Daniel P., Kunkel, Steven D., Fox, Daniel K., Bongers, Kale S., Bullard, Steven A., Dierdorff, Jason M., Adams, Christopher M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2014
Materias:	Metabolism
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031541/ https://www.ncbi.nlm.nih.gov/pubmed/24719321 http://dx.doi.org/10.1074/jbc.M114.556241

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