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Hypothyroidism and Bipolar Affective Disorder: Is There a Connection?

CONTEXT: Hypothalamic-pituitary-thyroid axis dysfunction in the pathophysiology of bipolar disorder has received less attention as compared with that in depressive disorder. AIMS: To study the prevalence of hypothyroidism in patients diagnosed with bipolar disorder and compare it with a population n...

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Autor principal: Menon, Bindu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031577/
https://www.ncbi.nlm.nih.gov/pubmed/24860210
http://dx.doi.org/10.4103/0253-7176.130966
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author Menon, Bindu
author_facet Menon, Bindu
author_sort Menon, Bindu
collection PubMed
description CONTEXT: Hypothalamic-pituitary-thyroid axis dysfunction in the pathophysiology of bipolar disorder has received less attention as compared with that in depressive disorder. AIMS: To study the prevalence of hypothyroidism in patients diagnosed with bipolar disorder and compare it with a population norm. SETTINGS AND DESIGN: The setting was the psychiatry inpatient unit of a tertiary care hospital. The design was retrospective and observational. SUBJECTS AND METHODS: A retrospective observational study was performed, referring to the case records of 84 cases of bipolar disorder admitted to the Department of Psychiatry in a Tertiary Referral Center during the year 2010-2012. The prevalence of hypothyroidism both subclinical as demonstrated by elevated thyroid stimulating hormone (TSH) levels (cut-off value 4.2 μU/ml) and overt hypothyroidism (fasting T4 <0.92 ng/dl and TSH >4.2 μU/ml) was calculated. This was compared with the population prevalence of hypothyroidism as determined by an epidemiological study carried out in the year 2009, in the same region. The correlation between hypothyroidism, gender, lithium prophylaxis and family history of mood disorder was computed. STATISTICAL ANALYSIS: Percentage prevalence of hypothyroidism in the sample was calculated and compared to a population norm. The correlation between hypothyroidism, gender, lithium prophylaxis and family history of mood disorder was computed using the odds ratio (OR). RESULTS: The total prevalence of hypothyroidism in both males and females in the bipolar group was comparable with that in the general population. There is a significant association between family history of mood disorder in first degree relatives and patients having hypothyroidism (OR 5.504 and P = 0.012). There were no statistically significant associations between thyroid abnormalities and age, duration of illness and lithium prophylaxis. CONCLUSIONS: There is no significant association between hypothyroidism and bipolar disorder. Family history of mood disorder and hypothyroidism show significant association. (OR -5.504 AND P = 0.012).
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spelling pubmed-40315772014-05-23 Hypothyroidism and Bipolar Affective Disorder: Is There a Connection? Menon, Bindu Indian J Psychol Med Original Article CONTEXT: Hypothalamic-pituitary-thyroid axis dysfunction in the pathophysiology of bipolar disorder has received less attention as compared with that in depressive disorder. AIMS: To study the prevalence of hypothyroidism in patients diagnosed with bipolar disorder and compare it with a population norm. SETTINGS AND DESIGN: The setting was the psychiatry inpatient unit of a tertiary care hospital. The design was retrospective and observational. SUBJECTS AND METHODS: A retrospective observational study was performed, referring to the case records of 84 cases of bipolar disorder admitted to the Department of Psychiatry in a Tertiary Referral Center during the year 2010-2012. The prevalence of hypothyroidism both subclinical as demonstrated by elevated thyroid stimulating hormone (TSH) levels (cut-off value 4.2 μU/ml) and overt hypothyroidism (fasting T4 <0.92 ng/dl and TSH >4.2 μU/ml) was calculated. This was compared with the population prevalence of hypothyroidism as determined by an epidemiological study carried out in the year 2009, in the same region. The correlation between hypothyroidism, gender, lithium prophylaxis and family history of mood disorder was computed. STATISTICAL ANALYSIS: Percentage prevalence of hypothyroidism in the sample was calculated and compared to a population norm. The correlation between hypothyroidism, gender, lithium prophylaxis and family history of mood disorder was computed using the odds ratio (OR). RESULTS: The total prevalence of hypothyroidism in both males and females in the bipolar group was comparable with that in the general population. There is a significant association between family history of mood disorder in first degree relatives and patients having hypothyroidism (OR 5.504 and P = 0.012). There were no statistically significant associations between thyroid abnormalities and age, duration of illness and lithium prophylaxis. CONCLUSIONS: There is no significant association between hypothyroidism and bipolar disorder. Family history of mood disorder and hypothyroidism show significant association. (OR -5.504 AND P = 0.012). Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC4031577/ /pubmed/24860210 http://dx.doi.org/10.4103/0253-7176.130966 Text en Copyright: © Indian Journal of Psychological Medicine http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Menon, Bindu
Hypothyroidism and Bipolar Affective Disorder: Is There a Connection?
title Hypothyroidism and Bipolar Affective Disorder: Is There a Connection?
title_full Hypothyroidism and Bipolar Affective Disorder: Is There a Connection?
title_fullStr Hypothyroidism and Bipolar Affective Disorder: Is There a Connection?
title_full_unstemmed Hypothyroidism and Bipolar Affective Disorder: Is There a Connection?
title_short Hypothyroidism and Bipolar Affective Disorder: Is There a Connection?
title_sort hypothyroidism and bipolar affective disorder: is there a connection?
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031577/
https://www.ncbi.nlm.nih.gov/pubmed/24860210
http://dx.doi.org/10.4103/0253-7176.130966
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