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Noninvasive ventilation in acute respiratory failure from respiratory syncytial virus bronchiolitis
OBJECTIVES: The present study focused on respiratory syncytial virus bronchiolitis with respiratory failure. The aim of the study was to determine whether noninvasive ventilation reduces the need for endotracheal intubation or slows the clinical progression of acute respiratory syncytial virus bronc...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Associação Brasileira de Medicina intensiva
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031822/ https://www.ncbi.nlm.nih.gov/pubmed/23917936 http://dx.doi.org/10.1590/S0103-507X2012000400014 |
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author | Nizarali, Zahara Cabral, Marta Silvestre, Catarina Abadesso, Clara Nunes, Pedro Loureiro, Helena Almeida, Helena |
author_facet | Nizarali, Zahara Cabral, Marta Silvestre, Catarina Abadesso, Clara Nunes, Pedro Loureiro, Helena Almeida, Helena |
author_sort | Nizarali, Zahara |
collection | PubMed |
description | OBJECTIVES: The present study focused on respiratory syncytial virus bronchiolitis with respiratory failure. The aim of the study was to determine whether noninvasive ventilation reduces the need for endotracheal intubation or slows the clinical progression of acute respiratory syncytial virus bronchiolitis by reducing the incidence of infectious complications. METHODS: The present study was a retrospective cohort study. Cohort A was comprised of children who were admitted to the pediatric intensive and special care unit from 2003-2005 before starting noninvasive ventilation; cohort B was comprised of children who were admitted to the pediatric intensive and special care unit from 2006-2008 after starting noninvasive ventilation. With the exception of noninvasive ventilation, the therapeutic support was the same for the two groups. All children who were diagnosed with respiratory syncytial virus bronchiolitis and respiratory failure between November 2003 and March 2008 were included in the cohort. Demographic, clinical and blood gas variables were analyzed. RESULTS: A total of 162 children were included; 75% of the subjects were less than 3 months old. Group A included 64 children, and group B included 98 children. In group B, 34 of the children required noninvasive ventilation. The distributions of the variables age, preterm birth, congenital heart disease, cerebral palsy and chronic lung disease were similar between the two groups. On admission, the data for blood gas analysis and the number of apneas were not significantly different between the groups. In group B, fewer children required invasive ventilation (group A: 12/64 versus group B: 7/98; p=0.02), and there was a reduction in the number of cases of bacterial pneumonia (group A: 19/64 versus group B: 12/98; p=0.008). There was no record of mortality in either of the groups. CONCLUSION: By comparing children with the same disease both before and after noninvasive ventilation was used for ventilation support, we verified a reduction in infectious complications and cases requiring intubation. |
format | Online Article Text |
id | pubmed-4031822 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Associação Brasileira de Medicina intensiva |
record_format | MEDLINE/PubMed |
spelling | pubmed-40318222014-06-02 Noninvasive ventilation in acute respiratory failure from respiratory syncytial virus bronchiolitis Nizarali, Zahara Cabral, Marta Silvestre, Catarina Abadesso, Clara Nunes, Pedro Loureiro, Helena Almeida, Helena Rev Bras Ter Intensiva Original Article OBJECTIVES: The present study focused on respiratory syncytial virus bronchiolitis with respiratory failure. The aim of the study was to determine whether noninvasive ventilation reduces the need for endotracheal intubation or slows the clinical progression of acute respiratory syncytial virus bronchiolitis by reducing the incidence of infectious complications. METHODS: The present study was a retrospective cohort study. Cohort A was comprised of children who were admitted to the pediatric intensive and special care unit from 2003-2005 before starting noninvasive ventilation; cohort B was comprised of children who were admitted to the pediatric intensive and special care unit from 2006-2008 after starting noninvasive ventilation. With the exception of noninvasive ventilation, the therapeutic support was the same for the two groups. All children who were diagnosed with respiratory syncytial virus bronchiolitis and respiratory failure between November 2003 and March 2008 were included in the cohort. Demographic, clinical and blood gas variables were analyzed. RESULTS: A total of 162 children were included; 75% of the subjects were less than 3 months old. Group A included 64 children, and group B included 98 children. In group B, 34 of the children required noninvasive ventilation. The distributions of the variables age, preterm birth, congenital heart disease, cerebral palsy and chronic lung disease were similar between the two groups. On admission, the data for blood gas analysis and the number of apneas were not significantly different between the groups. In group B, fewer children required invasive ventilation (group A: 12/64 versus group B: 7/98; p=0.02), and there was a reduction in the number of cases of bacterial pneumonia (group A: 19/64 versus group B: 12/98; p=0.008). There was no record of mortality in either of the groups. CONCLUSION: By comparing children with the same disease both before and after noninvasive ventilation was used for ventilation support, we verified a reduction in infectious complications and cases requiring intubation. Associação Brasileira de Medicina intensiva 2012 /pmc/articles/PMC4031822/ /pubmed/23917936 http://dx.doi.org/10.1590/S0103-507X2012000400014 Text en http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Nizarali, Zahara Cabral, Marta Silvestre, Catarina Abadesso, Clara Nunes, Pedro Loureiro, Helena Almeida, Helena Noninvasive ventilation in acute respiratory failure from respiratory syncytial virus bronchiolitis |
title | Noninvasive ventilation in acute respiratory failure from respiratory
syncytial virus bronchiolitis |
title_full | Noninvasive ventilation in acute respiratory failure from respiratory
syncytial virus bronchiolitis |
title_fullStr | Noninvasive ventilation in acute respiratory failure from respiratory
syncytial virus bronchiolitis |
title_full_unstemmed | Noninvasive ventilation in acute respiratory failure from respiratory
syncytial virus bronchiolitis |
title_short | Noninvasive ventilation in acute respiratory failure from respiratory
syncytial virus bronchiolitis |
title_sort | noninvasive ventilation in acute respiratory failure from respiratory
syncytial virus bronchiolitis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031822/ https://www.ncbi.nlm.nih.gov/pubmed/23917936 http://dx.doi.org/10.1590/S0103-507X2012000400014 |
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